Ethyl dihydrogen phosphate

Rare earths Bis (2-ethyl-hexyl) hydrogen phosphate and 2-ethyl dihydrogen phosphate Cis silica ICPMS [650]... 

Ethyl dihydrogen phosphate c2h7o4p NA Identified in soil ... 

Then 0.75 cc of freshly distilled ethyl formate is added. The air in the system is replaced with nitrogen and 150 mg of sodium hydride (as a 57% dispersion in mineral oil) is added. The mixture is stirred under nitrogen at room temperature for three hours. Then 15 cc of a saturated aqueous solution of sodium dihydrogen phosphate is added and the product is extracted into ether. 

For many years such media have been based on strong salt solutions, e.g. calcium chloride brines. Sodium dichromate has been used (seep. 17 26), but recently other inhibitors have been claimed to be effective. One patent quotes N-alkyl-substituted alkanolamines, e.g. 2-ethyl ethanolamine -I- BTA at pH A mixture of hydrazine hydrochloride -i- BTA has been claimed as well as a mixture of gelatin -h triethanolamine -h potassium dihydrogen phosphate . Other examples are to be found in the patent literature and the above are quoted to illustrate the diversity of chemicals that may be used. 

The furosemide extraction procedure was later examined for potential application in the analysis of thiazide diuretics in milk. Since this procedure could not provide sufficiently clean extracts for thiazides, additional acidic and basic extraction procedures were evaluated (557). Thus, milk was deproteinized with trichloroacetic acid, phosphoric acid, or potassium dihydrogen phosphate and centrifuged. The supernatants were extracted with ethyl acetate, evaporated to dryness, reconstituted in mobile phase, and analyzed by liquid chromatography. The recoveries in most cases were low and widely variable. Basic extraction, on the other hand, with sodium bicarbonate/potassium carbonate mixture or potassium monohydrogen phosphate followed by extraction with ethyl acetate also gave poor recoveries in most cases. It appears that a significant degradation of chlorothiazide occurred under the basic conditions. 

To 5.69 g of this acetal in 410 ml of t-butanol and 11 ml of water was added a mixture of 5.80 g of potassium carbonate, 22,8 g of sodium periodate, and 270 mg of potassium permanganate in 1230 ml of water. The reaction mixture was stirred at 20-25°C for 20 hours and concentrated in vacuo to remove t-butanol. Ethylene glycole (0.5 ml) was added and reaction mixture extracted with 1 1 ether-benzene to remove neutral material. The aqueous layer acidified with solid sodium dihydrogen phosphate and extracted 4 times with 1 1 ethyl acetate-benzene. The organic layer was dried over sodium sulfate and evaporated to dryness in vacuo affording (+/-)-3-acetyl-2a-(2-carboxyethyl)-5-oxo-ip-cyclopentaneheptanoic acid methyl ester, 5-cyclic ethylene acetal as a mixture of the 3a and 3p isomers. 

The ether extracts are extracted with 2 N sodium hydroxide and the sodium hydroxide extracts are acidified with sodium dihydrogen phosphate and extracted again into ether. The ether extract is evaporated to dryness to give about 500 mg of a crude product. From the ether solution there is obtained about 290 mg of yellow crystals, MP 220° to 236°C which is 17a,20,20,21-bis(methylenedioxy)-lip-formyloxy-2-hydroxy-methylene-6,16a-dimethyl-4,6-pregnadiene-3-one. The analytical sample is recrystallized from ethyl acetate and has a melting point of 249° to 255°C, [a]D27 -217°, I R 5.81 and 8.37 pm. From the mother liquor is obtained about 127 mg of 17a,20,20-21-bis(methylenedioxy)-lip-hydroxy-2-hydroxymethylene-6,16a-dimethyl-4,6-pregnadiene-3-one. The analytical sample is recrystallized from ether and has a melting point of 200° to 204°C, [a]D27 -197°, IR 6.05 to 6.2 and 6.4 p. 

SYNS CY-39 3-(2-(DIMETHYLAMINO)ETHYL)-lH-INDOL-4-OL DIHYDROGEN PHOSPHATE ESTER 3-2 -DIMETHYLAiMINOETHYLINDOL-4-PHOSPHATE 3-(2-DIMETHYLAMINOETHYL)INDOL-4-YL DIHYDROGEN PHOSPHATE INDOCYBIN PSILOCIN PHOSPHATE ESTER PSILOCIPIN PSILOTSIBIN TEON-ANACATL... 

DIMETHYLAMINO)ETHYL)-lH-INDOL-4-OL DIHYDROGEN PHOSPHATE ESTER see PHU500... 

At least eighteen phenylethylamines have been examined by x-ray crystallography. Among these are phenylethylamine hydrochloride (3 ), ephedrine hydrochloride (31), ephedrine monohydrogen phosphate monohydrate (32), ephedrine dihydrogen phosphate (33), dopamine hydrochloride (34), 5-hydroxydopamine hydrochloride (35), 6-hydroxydopamine hydrochloride (36), epinephrine hydrogen tartrate (37), norepinephrine hydrochloride (38), isoproterenol sulfate (39), 2,4,5-trimethoxyamphetamine hydrochloride (40), 4-ethyl-2,5-dimethoxyamphetamine (41), mescaline hydrobromide (42), and mescaline hydrochloride (43). 

Column Partisil 10-0DS (250x4.6 mm ID), mobile phase 0.25 M potassium dihydrogen phosphate (pH 2.7) containing 17% acetonitrile, flow rate 2 ml/min, detection UV 200 and 235 nm, column temperature 40°C. Peaks 1, benzoylecgonlne 2, cocaine 3, benzoyl ecgonine ji-ethyl ester (internal standard). 

Reagents. Carbaryl (Fluka, USA), Sodium dodecyl sulfate (SDS) (Fluka, USA), Ethyl alcohol (Duksan, Korea), Sodium hydrogen phosphate (Na2HP04) (Merck, Germany), Sodium dihydrogen phosphate (NaH2P04) (Merck, Germany). 

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