Ecgonine, benzoyl

Leute R., Bolz G. Nitrogen derivates of benzoyl ecgonine. U.S. patent 3888 866, 1975. 

Erythroxylon, Spadic, Coca leaves, Cuca, Hayo, Ipado, Coca Folia Fr. Feuilles de Coca Ger. Kokablatter Cocain, Methyl-benzoyl-ecgonine Br. Cocaina Fr. Cocaine Ger. Cocainum, and Kokaina are some of the names by which the substances is known. 

Fluorescence polarization immunoassay using substituted benzoyl ecgonine derivative, (V), developed by Ungemach (3) was used to monitor/detect cocaine and cocaine metabolites. 

Fraction C benzoyl-ecgonine. morphine. 6-acetyl morphine, codeine. Detection limit... 

Brunner, H., Balabanova, S., Homoki, J., Wolf, H. U., Determination of Benzoyl Ecgonine in Human Scalp Hair Following Cocaine Abuse by Gas Chromatography-Mass Spectrometry (GC/MS), Beitr. Gerichtl. Med., 46,127,1988. 

Althongh cocaine occurs naturally in plant material, a number of related, naturally occurring alkaloids based upon the tropane structnre may be isolated from the plant material and subsequently converted into cocaine. These inclnde ecgonine, ecgonine methyl ester and benzoyl ecgonine There are two principle routes by which extraction can be achieved prior to cocaine synthesis. 

Ecgonine like tropine does not occur as such in plants. The partially hydrolyzed cocaine, viz., the benzoyl ecgonine, is a natural plant alkaloid. An ester analogous to cocaine with the radical of cinnamic acid, CeHs—CH = CH—COOH, in place of that of benzoic acid, is a natural alkaloid in Java coca leaves and is known as cinnamyl cocaine. 

Abused drugs and metabolites (includes benzoyl-ecgonine, morphine, heroin, methamphetamine, codeine, amphetamine, cocaine, methadone, benzodiazepines)... 

Toxicity associated with chronic use is not as well described as acute toxicity, but it appears to include cerebral atrophy, cardiomyopathy, and chronic pulmonary disease. Cocaine and its metabolites are most commonly identified in patient urine. An immunoassay directed toward identification of benzoyl-ecgonine will frequently indicate the presence of cocaine and its metabolites for many days after use. The duration of qualitatively detected cocaine and metabolites in urine is probably dose dependent and may be up to 3 weeks in length. Chronic use of cocaine may lead to dependence. 

Several other methods have been proposed for the conversion of ecgonine into cocaine —ecgonine is benzoylated by heating with benzoic anhydride or benzoyl chloride, or by heating the hydrochloride with benzoyl chloride, and the resulting benzoyl ecgonine esterified by... 

Benzoyl-ecgonine-methyl-ester Benzol-methyl-ecgonine Cocainum Cocaine, Fr. Cod. Cocain, Kokain, G. 

Column Partisil 10-0DS (250x4.6 mm ID), mobile phase 0.25 M potassium dihydrogen phosphate (pH 2.7) containing 17% acetonitrile, flow rate 2 ml/min, detection UV 200 and 235 nm, column temperature 40°C. Peaks 1, benzoylecgonlne 2, cocaine 3, benzoyl ecgonine ji-ethyl ester (internal standard). 

N-Methyl-l-benzoyl ecgonine (C17H21NO4) a-Methyl benzylpenilloate (C16H22N2O3S) Metbylcaffeine (C9H12N4O2)... 

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