Ethoxyacetic acid

ETHOXYETHANOL (EGEE) and 2-ETHOXYETHYL ACETATE (EGEEA) 2-Ethoxyacetic acid in urine End of shift at end of workweek 100 mg/g creatinine ... 

Novel isosteres 545 of the antiviral agent acyclovir were synthesized in three stages (84JHC697) by dehydrative coupling of 3-amino-6-aminomethyl[ 1,2,4]triazin-5-(4//)-one with 2-(benzoyloxy)ethoxyacetic acid to give the respective amide that cyclized and deprotected to give 545. It showed no activity against herpes simplex virus types I and II in cell culture (Scheme 112). 

Other difunctional aliphatic carboxylic acids, e.g. lactic add, pyruvic acid, ethoxyacetic acid. 

After treatment of XXXVI with aqueous barium hydroxide, the liquor contained formic, methoxyacetic, and ethoxyacetic acids, methoxyacetone, and ethoxyacetone, produced by the two modes of cleavage XXXVIa and XXXVIb. Formic acid was converted with red mercuric oxide to carbon dioxide this was recovered as barium carbonate, the radioactivity of which was a measure of the C14 incorporated into Cl of kojic acid in the biosynthetic process. The alkoxyacetones were removed from the liquor by steam distillation, and converted to iodoform and a mixture of methoxy- and ethoxy-acetic acids. The iodoform was recovered by filtration its radioactivity indicated the proportion of C14 incorporated into C4. The alkoxy-... 

Because EE is well absorbed through the skin, ambient monitoring of environmental exposure level is not considered to be an accurate method of determining absorbed dose. Biological monitoring of the ethoxyethanol metabolite 2-ethoxyacetic acid in urine has been shown to be an effective indicator of absorbed dose in workers. ... 

C2H6O.CH2.CO(N3) tnw 129.12, N 32.54%, yel pungent oil, causing tears sol in ale, eth, benz expl on heating prepd from ethoxyacetic acid bydrazide and HNO2 Refs 1) Beil 3, (94) 2) T. Curtins, JPrakt-... 

Ethyl glycolic Acid, Ethoxyacetic Acid or Glycolic Ethylether... 

SYNS ACETIC ACID, ETHOXY- 2-ETHOXYACETIC ACID... 

Repeated exposures have resulted in increased oligospermia (low sperm counts) and azoospermia (dead sperm) in male shipyard workers, but there has been some skepticism about these reports due to small sample size. One case controlled study found significant ethoxyacetic acid presence in infertile men. An increased risk of spontaneous abortion and lowered fertility was shown in an epidemiological study of women exposed to mixtures of ethylene glycol ethers. 

Ph3Bi(OOtBu)2 oxidizes a methyl group in diethyl ether to afford ethoxyacetic acid as the initial product [350], The peroxide also oxidizes toluene and ethylbenzene to benzaldehyde and acetophenone, respectively, via radical intermediates [343]. Thiophenol, benzophenone hydrazone, and hydrazobenzene are efficienfly oxidized by organobismufh(V) compounds [341a, c]. 2,6-Dialkylphenols are oxidatively dimerized by PhsBiCOs [300e]. 

Veulemans H, Groesceneken D, Maschelein R, et al. 1987.Field study of the urinary excretion of ethoxyacetic acid during repeated daily exposure to the etliyl ether of ethylene glycol and the ethyl ether of ethylene glycol acetate. Scand J Work Environ Health 13 239-242. 

Ethoxyacetic acid was first prepared by Heintz by the reaction of chloroacetic acid with sodium ethylate. The procedme described above is essentially that of Sommelet. Ethoxyacetic acid has also been prepared by hydrolysis of ethoxyacetonitrile with concentrated hydrochloric acid and by the action of excess sodium ethylate on 1,1,1,2-tetrachlorethane and on a,/3-dichloro-vinyl ethyl ether. A recent patent reports a synthesis from diethyl ether and carbon dioxide at high pressure. 

---