Escherichia coli fatty acid synthase

The second type of arrangement observed for sequentially related enzymes is exemplified by the Escherichia coli fatty acid synthase (see chapter 18). This synthase is a complex of most of the enzymes involved in fatty acid synthesis. The intermediates in this case are bound to the enzyme complex until synthesis is complete. 

All the reactions in the synthetic process are catalyzed by a multienzyme complex, fatty acid synthase. Although the details of enzyme structure differ in prokaryotes such as Escherichia coli and in eukaryotes, the four-step process of fatty acid synthesis is the same in all organisms. We first describe the process as it occurs in A1, coli, then consider differences in enzyme structure in other organisms. 

What are the characteristics of the fatty acid synthase in the bacterium Escherichia coli that distinguish it from the mammalian multienzyme complex ... 

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Enzymes. The structures of both acetyl-CoA carboxylase and fatty acid synthase in plants more closely resemble their counterparts in Escherichia coli than those in animal cells. For example, in E. coli and plants, each of the enzyme activities of fatty acid synthase is found on a separate protein. 

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