Enoyl-acyl carrier protein reductase

Enoyl-acyl carrier protein reductase 777 Enoyl hydratase 681 Enoyl reductase 766... 

Enoyl-acyl carrier protein reductase carboxamide inhibitors were used to build CoMFA model (tested with ten compounds, it2 = 0.88), followed by the de novo molecule design software LEAPFROG0... 

Docking and molecular dynamics were used to study the binding of the isoniazid metabolite INH-NAD to the enoyl-acyl carrier protein reductase... 

Kumar A, Siddiqi MI (2008) CoMFA based de novo design of pyrrolidine carboxamides as inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. J Mol Model 14 923-935... 

Kumar A, Siddiqi MI (2010) Receptor based 3D-QSAR to identify putative binders of Mycobacterium tuberculosis Enoyl acyl carrier protein reductase. J Mol Model 16 877-893... 

Heath, R.J. and C.O. Rock. 1995. Enoyl-acyl carrier protein reductase (fabl) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli. J. Biol. Chem. 270, 26538-26542. 

Triclocarban works as a disinfectant because it disables an enzyme called enoyl-acyl-carrier-protein reductase, or... 

Triclosan (TRY-klo-san) is a white crystalline powder with antimicrobial properties that make it a useful ingredient in soaps, cosmetics, acne medications, deodorants, foot sprays and foot powders, toothpastes, and mouthwashes. It acts as an antimicrobial by inhibiting the action of an enzyme called enoyl-acyl carrier-protein reductase (ENR) that bacteria and fungi need to survive. The enzyme is used in the synthesis of fatty acids from which cell membranes are constructed. Having lost the ability to manufacture cell walls, bacteria and fungi die. The ENR enzyme is not present in humans, so triclosan has no effect on the human body. 

Fig. 6 Metabolic activation of isoniazid. Reactive metabolites are responsible for the pharmacology and toxicology of isoniazid. In Mycobacterium tuberculosis, generation of the isonicotinoyl radical leads to the formation of an adduct with NADH, which in turn inhibits an enoyl-acyl carrier protein reductase (InhA) (Rawat et al. 2003 Rozwarski et al. 1998)...

Nicola, G., Smith, C.A., Lucumi, E., Kuo, M.R., Karagyozov, K., Fidock, D.A., Sacchettini, J.C., and Abagyan, R. (2007) Discovery of novel inhibitors targeting enoyl-acyl-carrier protein reductase in Plasmodium falciparum by structure-based virtual screening. Biochemical and Biophysical Research Communications, 358, 686-691. 

Baker, M.E. (1995) Biochem. J., 309, 1029-1030, Enoyl-acyl-carrier-protein reductase and Mycobacterium tuberculosis InhA do not conserve the Tyr-Xaa-Xaa-Xaa-Lys motif in mammalian llp-and 1 P-hydroxysteroid dehydrogenases and Ehosoplula alcohol dehydrogenase. 

Carrol. L (1942) Through the looking-glass and what Alice found there.. Macmillan and Co Ltd, London. Joshi. A. K. Smith. S., (1993) Construction of a cDNA encoding the multifimctional animal fatty acid synthase and expression in Spodoptera fmgiperrda cells using baculovirus vectors. Biochem, J. 296 143-149. Kater. M. M., et al., (1991) cDNA cloning and expression ofBrassica napus enoyl-acyl carrier protein reductase in Escherichia coli.. Plant Mol. Biol. 17 895-909. 

Rafferty. J. B., et al., (1995) Common themes in redox chemistry emerge from the X-ray structure of oil seed rape (Brassica napus) enoyl acyl carrier protein reductase. Structure 3 927-38. 

Cottingham, I.R., Austin, A., Sidebottom, C. and Slabas, A.R. (1988) Purified enoyl-[acyl-carrier-protein] reductase from rape seed Brassica napus) contains two closely related polypeptides which differ by a six-amino-acid N-terminal extension. Biochim. Biophys. Acta 954, 201-207. 

Kalinski, A., Loer, D.S., Weisemann, J.M., Matthews, B.F. and Herman, E.M. (1991) Isoforms of soybean seed oil body membrane protein. Plant Mol. Biol. 17, 1095-1098. Kater, M.M., Koningstein, G.M., Nijkamp, J.J. and Stuitje, A.R. (1991) cDNA cloning and expression of Brassica napus enoyl-acyl carrier protein reductase in Escherichia coli. Plant Mol. Biol. 17, 895-909. 

Shimakata, T. and Stumpf, P.K. (1982c) Purification and characterization of beta-keto-acyl-carrier-protein reductase, beta-hydroxyacyl-carrier-protein dehydrase and enoyl-acyl-carrier-protein reductase from Spinacia oleracea leaves. Arch. Biochem. Biophys. 218, 77-91. 

Kater MM, Koningstein GM, Nijkamp HJJ and Stuitje AR. cDNA cloning and expression of Brassica napus enoyl-acyl carrier protein reductase in Escherichia coli. Plant Mol Biol 1991 17 895-909. 

Tombs MR Induction, purification and characterisation of NADH-specific enoyl-acyl carrier protein reductase from seeds of oil seed rape Brassica napus). Biochem Biophys Acta 1986 877 271-280. 

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