Epidermal tumors

K7. Kirchheimer, J. C., Wojta, J., Christ, G., and Binder, B. R., Proliferation of a human epidermal tumor cell line stimulated by urokinase. FASEB J. 1, 125-128 (1987). 

Nazini MN, Dykes RI, Marks R. Epidermal growth factor receptors in human epidermal tumors. Br J Dermatol. 1990 123 153-161. 

Mueller DK, Kopp SA, Marks F, Seibert K, Fuerstenberger G. Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors suppression of skin tumor promotion by inhibition of prostagalndin H synthase-2. Mol Carcinog 1998 23 36-44. 

Pariza, M.W., and Hargraves, W.A. (1985) A Beef-Derived Mutagenesis Modulator Inhibits Initiation of Mouse Epidermal Tumors by 7,12-Dimethylbenz[a] anthracene, Carcinogenesis 6, 591-593. 

Blunt dissection is a fast, elementary, usually nonscarring surgical procedure used to remove rrarts and other epidermal tumors. Unlike ED C and excision, it does not disturb normal tissue. 

Whereas epidermal growth factor (EGF) enhances the radiosensitivity of human squamous ceU carcinoma cells in vitro (197), addition of EGF to hormone-deprived MCE-7 breast cancer cells prior to irradiation results ia iacreased radioresistance (198). An anti-EGE-receptor monoclonal antibody blocks the abiUty of EGE to enhance growth and radioresistance. Tumor cells, the growth of which is stimulated by EGE, appear to be protected those where growth is iohibited are sensitized (198). 

Figure 43-13. Several signal transduction pathways converge on CBP/p300. Ligands that associate with membrane or nuclear receptors eventually converge on CBP/p300. Several different signal transduction pathways are employed. EGF, epidermal growth factor GH, growth hormone PrI, prolactin TNF, tumor necrosis factor other abbreviations are expanded in the text.

WEI H, TYE L, BRESMiK E and BiRT D F (1990) Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornilthine decarboxylase and skin tumor promotion in mice . Cancer Res, 50, 499-502. 

Pence, B.C. and Reiners, J.J. (1987). Murine epidermal xanthine oxidase activity correlation with degree of hyperplasia induced by tumor promoters. Cancer Res. 47, 6388-6392. 

Bergmann F, Breinig M, Hopfner M, et al. Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2 novel chemotherapeutic targets in pancreatic endocrine tumors. Am. J. Gastroenterol. 2009 104 171-181. 

In another study, CPMV particles that displayed a peptide derived from the epidermal growth factor receptor variant III (EGFRvIII) elicited specific antibody responses in mice against the peptide and protected mice from tumor challenge [45]. 

Examples of the early application of recombinant DNA technology in medicine are the development of recombinant human growth hormone human insulin human interferons, thought to have anticancer activity in addition to antiviral activity interleukins (regulatory proteins from lymphocytes that are believed to be important in the treatment of immunodeficiency diseases and cancer) tumor necrosis factor epidermal and bone marrow progenitor cell growth factors and the production of vaccines (Table 12.1). 

---