Epidermal growth factor radiosensitizer

Whereas epidermal growth factor (EGF) enhances the radiosensitivity of human squamous ceU carcinoma cells in vitro (197), addition of EGF to hormone-deprived MCE-7 breast cancer cells prior to irradiation results ia iacreased radioresistance (198). An anti-EGE-receptor monoclonal antibody blocks the abiUty of EGE to enhance growth and radioresistance. Tumor cells, the growth of which is stimulated by EGE, appear to be protected those where growth is iohibited are sensitized (198). 

Sartor CL Biological modifiers as potential radiosensitizers targeting the epidermal growth factor receptor family. Semin Oncol 2000 27(6 Suppl 11) 15-20. 

Huang SM, Bock JM, Harari PM. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999 59 1935-1940. 

Contessa JN, Reardon DB, Todd D, et al. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. Clin Cancer Res 1999 5 405 111. 

Toulany M, Kasten-Pisula U, Brammer I et al (2006) Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair. Clin Cancer Res 12 4119-4126 Valerie K, Yacoub A, Hagan MP etal (2007) Radiation-induced cell signaling inside-out and outside-in. Mol Cancer Ther 6 789-801... 

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