EPIC study

Health benefits of carotenoids are related to their bioavailability and thus then-absorption. Plasma concentration is considered a good biomarker of fruit and vegetable consumption. Table 3.1.1 shows plasma carotenoid levels in EPIC study subjects from 16 European locations. EPIC was the first large cross-sectional study analyzing plasma carotenoid levels in several European populations. ... 

Mean Plasma Carotenoid Levels (timol/l) in EPIC Study Subjects from... 

Echemann M, Zannad F, Briancon S, JuUhere Y, Mertes PM, Virion JM, Villemot JP. Determinants of angiotensin-converting enzyme inhibitor prescription in severe heart failure with left ventricular systolic dysfunction the EPICAL study. Am Heart J 2000 139(4) 624-31. 

A racemase is a difficult enzyme with which to study product inhibition, since Teq = I and, if one puts in enough product to inhibit the enzyme, one is near equilibrium or the reaction goes backward. In their epic studies on proline racemase, Knowles and co-workers solved this problem by using optical rotation to... 

The association of nut intake and CHD mortality was exanfined in 399,633 subjects, including 1158 cases, enrolled in the EPIC study [59]. When comparing the highest (> 13 g/day) and the lowest (<1 g/day) nut intake categories, and after adjusting for coronary risk factors and dietary variables, the hazard ratio (HR) was 0.71 [95% confidence interval (Cl), 0.51-0.98]. An HR of 0.74 (0.57-0.96) was estimated for every 8 g/day of increased nut intake, and after adjustments, the HR was 0.89 (0.74-1.08). Nut intake was associated with a dcCTcased risk of CHD mortality. In approximately half of a population that rarely consumes nuts, an intake of only two servings of nuts per week (8 g/day) may reduce CHD mortality by 11%. 

In 2004, Jenab et al. [141] investigated the effect of nut and seed intake on colorectal cancer in men and women participating in the EPIC study across Europe. Total nut intake was determined from country-specific dietary questionnaires for 855 (327 men and 528 women) colon cancer cases, 474 (215 men and 259 women) rectal cancer cases, and 478,040 (141,988 men and 336,052 women) total subjects. Division of the data into colon and rectal cancers showed a significant protective effect of nut intake on colon cancer in females at the highest quintile of intake, which was greater than 6g daily. The results showed a significant protective effect of increased nut intake on colon cancer in women, with no effects on rectal cancer for either gender. 

Zamora-Ros R, Agudo A, Lujan-Barroso L, et al. Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am Clin Nutr. 2012 96 1398-1408. 

A. Vincent, J. L. Bihari and D. J. Suter et al.. The prevalence of nosocomial infection in intensive care units in Europe results of the European Prevalence of Infection in Intensive Care (EPIC) Study, J. Am. Med. Assoc., 1995, 274, 639-644. 

Consoli D, Bosco D, Postorino P, Galati F, Plastino M, Perticoni GF, et al. EPIC Study. Levetiracetam versus carbamazepine inpatients with late poststroke seizures a multicenter prospective randomized open-label study (EplC Project). Cerebrovasc Dis 2012 34(4) 282-9. 

Cappellini MD, Porter J, El-Beshlawy A, Li CK, Seymour JF, Elalfy M, et al. Tailoring iron chelation by iron intake and serum ferritin the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias. Haematologica April 2010 95(4) 557-66. 

NP is the second most common hospital-acquired infection and is the leading cause of death in this category. The incidence of NP ranges from 4 to 50 cases per 1000 admission in community hospitals and general medical wards, and 120-220 cases per 1000 admission in intensive care units (ICUs) or among patients requiring MV. The EPIC study (2), a large... 

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