Eosinophilic bronchitis

Sastre J, Qnirce S. Sensitizing agents indncers of occupational asthma, hypersensitivity pnenmonitis and eosinophilic bronchitis. Accessed on September 2,2007. Available at http //www.worldallergy.org/professionaPahergic diseases center/occnpational ahergens/index.shtml... 

Asthma may present predominantly with cough, often nocturnal, and the diagnosis is supported by the presence of bronchial hyperresponsiveness. Three other conditions, cough-variant asthma, atopic cough, and eosinophilic bronchitis, are related... 

Brightling CE, Ward R, Wardlaw AJ, Pavord ID (2000) Airway inflammation, airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis, Eur Respir J 15 682-686... 

Brightling CE, Ward R, Goh VV et al (1999) Eosinophilic bronchitis is an important cause of cough. Am J Respir Crit Care 160 406 10... 

Lung diseases with possible and/or mild pulmonary eosinophilia Asthma, eosinophilic bronchitis Organizing pneumonia Idiopathic interstitial pneumonias Langerhans cell granulomatosis Sarcoidosis Lymphoma... 

Eosinophilic bronchitis defined by a high percentage of eosinophils (up to 40%) in induced sputum is a cause of chronic cough, with normal lung function and absence of bronchial hyperreactivity (46-48). Prolonged treatment with inhaled corticosteroids may be beneficial. Eosinophilic bronchitis is distinct from bronchial asthma, although it may in some cases evolve over time to irreversible airflow obstruction without asthma or to genuine asthma (49,50). Eosinophilic pneumonia does not occur. 

Gibson PG, Dolovich J, Denburg J, et al. Chronic cough eosinophilic bronchitis without asthma. Lancet 1989 1 1346 1348. 

Gibson PG, Fujimura M, Niimi A. Eosinophilic bronchitis clinical manifestations and implications for treatment. Thorax 2002 57 178 182. 

Park SW, Lee YM, Jang AS, et al. Development of chronic airway obstruction in patients with eosinophilic bronchitis. A prospective follow-up study. Chest 2004 125 1998-2004. 

Brightling CE, Woltmann G, Wardlaw AJ, et al. Development of irreversible airflow obstruction in a patient with eosinophilic bronchitis without asthma. Eur Respir J 1999 14 1228-1230. 

An increased number of polymorphonuclear granulocytes in sputum often suggests continual bronchial irritation, whereas an increased number of eosinophils may suggest an allergic component. The most common bacterial isolates (expressed in percentages of total cultures) identified from sputum culture in patients experiencing an acute exacerbation of chronic bronchitis are as follows ... 

Zhu J, Qiu YS, Majumdar S, Gamble E, Matin D, Turato G, Fabbri LM, Barnes N, Saetta M, Jeffery PK. Exacerbations of Bronchitis Bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants. Am. J. Respir. Crit. Care Med. 2001 164 109-116. 

Sur, S., Crotty, T. B Kephant, G. M., Hyma, B. A., Colby, T. V., Reed, C. E., Hunt, L. W., and Gleich, G. J. (1993) Sudden onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa Am. Rev. Respir. Dis. 148,713-719. Chanez, P., Enander, I., Jones, I., Godard, P., and Bousquet, J. (1996) Interleukin 8 in bron-choalveolar lavage of asthmatic and chronic bronchitis patients. Int. Arch. Allergy Immunol. Ill, 83-88. 

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