Cough-variant asthma

Asthma may present predominantly with cough, often nocturnal, and the diagnosis is supported by the presence of bronchial hyperresponsiveness. Three other conditions, cough-variant asthma, atopic cough, and eosinophilic bronchitis, are related... 

Fujimura M, Abo M, Ogawa H, Nishi K, Kibe Y, Hirose T, Nakatsumi Y, Iwasa K (2005) Importance of atopic cough, cough variant asthma and sinobronchial syndrome as causes of chronic cough in the Hokuriku area of Japan. Respirology 10 201-207 Gracely RH, Undem BJ, Banzett RB (2007) Cough, pain and dyspnoea Similarities and differences. Pulm Pharmacol Ther 20 433 37... 

Nishitsuji M, Fujimura M, Oribe Y, Nakao S (2007) Effect of montelukast in a guinea pig model of cough variant asthma. Puhn Pharmacol Ther 2008 21(1) 142-5. 

Zalirlukast, a cysteinyl leukotriene antagonist, has shown therapeutic efficacy in cough-variant asthma, even in patients unresponsive to inhaled bronchodilators and corticosteroids (Dicpinigaitis et al. 2002), whist a similar drug, montelukast has also... 

Nakajima T, Nishimura Y, Nishiuma T, Kotani Y, Nakata H, Yokoyama M (2006) Cough sensitivity in pure cough variant asthma ehcited using continuous capsaicin inhalation. AUergol Int 55 149-155... 

Lee SY, Kim MK, Shin C, Shim JJ, Kim HK, Kang KH, Yoo SH, In KH (2003) Substance P-immunoreactive nerves in endobronchial biopsies in cough-variant asthma and classic asthma. Respiration 70 49-53... 

Cough is sometimes the only symptom in asthma. In snch circumstances and in the absence of airflow obsttuction, the condition cough variant asthma may be considered. Like classic asthma, the nature of airway inflammation in cough-variant... 

Fig. 5 Citric acid cough challenge in a patient with cough-variant asthma the effect of inhaled corticosteroids...

Niimi A, Amitani R, Suzuki K, et al. Eosinophilic inflammation in cough variant asthma. Eur Respir J 1998 11 1064—1069. 

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