Deuterium exchange mass spectrometry

Woods, V.L. Jr. Hamuro, Y High resolution, high-throughput amide deuterium exchange-mass spectrometry (DXMS) determination of protein binding site structure and... [Pg.373]

Hamuro, Y. Coales, S.J. Southern, M.R. Nemeth-Cawley, J.F. Stranz, D.D. Rod, G.P. Rapid analysis of protein structure and dynamics by hydrogen/deuterium exchange mass spectrometry. J. Biomol. Tech. 2003,... [Pg.375]

Chalmers, M.J. Busby, S.A. Pascal, B.D. He, Y. Hendrickson, C.L. Marshall, A.G. Griffin, P.R. Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry. Anal. Chem. 2006. [Pg.375]

Protein-targeting Drug Discovery Guided by Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS)... [Pg.377]

Hamuro Y., Burns L.L., Canaves J.M., Hoffman R.C., Taylor S.S., Woods V.L. Jr domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). J. Mol. Biol. [Pg.395]

DDBJ—see EMBL DLS—dynamic light scattering DM—donkey s milk DNA—deoxyribonucleic acid DNCB—2,4-dinitrochlorobenzene DSC—differential scanning calorimetry DTH—delayed cellular hypersensitivity DXMS—deuterium exchange mass spectrometry EAACI—European Academy of Allergology and Clinical Immunology EAR—early anaphylactic phase ECFA—eosinophil chemotactic factors of anaphylaxis ECP—eosinophil cationic protein EDN—eosinophil-derived neurotoxin eHF—extensively hydrolyzed formula ELISA—enzyme-linked immunosorbent assay... [Pg.449]

HXMS Hydrogen-deuterium exchange mass spectrometry... [Pg.136]

Resing, K.A., Ahn, N.G. (1998) Deuterium exchange mass spectrometry as a probe of kinase protein kinase activation. Analysis of wild-type and constitutively active mutants of MAP kinase kinase-1. [Pg.35]

Kipping, M., Schierhom, A. (2003) Improving hydrogen/deuterium exchange mass spectrometry by reduction of the back-exchange effect. Journal of Mass Spectrometry, 38 (3), 271-276. [Pg.35]

Pan, J., Han, J., Borchers, C.H., Konermann, L. (2009) Hydrogen/deuterium exchange mass spectrometry with top-down electron capture dissociation for characterizing structural transitions of a 17 kDa protein. J Am Chem Soc, 131 (35), 12801-12808. [Pg.51]

Houde, D Berkowitz, S.A., Engen, J.R. (2011) The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies. J Pharm Sci, 100 (6), 2071-2086. [Pg.52]

Lindner, R., Lou, X., Reinstein, J., et al. (2014) Hexicon 2 Automated processing of hydrogen-deuterium exchange mass spectrometry data with improved deuteration distribution estimation. J Am Soc Mass Spectrom, 25 (6), 1018-1028. [Pg.52]

Zhang, Z., Zhang, A., Xiao, G. (2012) Improved protein hydrogen/deuterium exchange mass spectrometry platform with fully automated data processing. Anal Chem, 84 (11), 4942-4949. [Pg.53]

Fajer, P.G., Bou-Assaf, G.M., Marshall, A.G. (2012) Improved sequence resolution by global analysis of overlapped peptides in hydrogen/deuterium exchange mass spectrometry. J Am Soc Mass Spectrom, 23 (7), 1202-1208. [Pg.53]

Y. Hamuro, S. J. Coales, M. R. Southern, J. F. Nemeth-Cawley, D. D. Stranz and P. R. Griffin. (2003) Rapid Analysis of Protein Structiue and Dyntunics by Hydrogen/Deuterium Exchange Mass Spectrometry,... [Pg.70]

D. Houde, S. A. Berkowitz and J. R. Engen. (2011) The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies, Journal of Pharmaceutical Sciences, 100 (6),... [Pg.70]

K. M. Burns, M. Rey, C. A. H. Baker and D. C. Schriemer. (2013) Platform Dependencies in Bottom-up Hydrogen/Deuterium Exchange Mass Spectrometry, Molecular Cellular Proteomics, 12 (2), 539-548. [Pg.71]

M. J. Chalmers, S. A. Busby, B. D. Pascal, Y. He, C. L. Hendrickson, A. G. Marshall and P. R. Griffin. (2006) Probing Protein Ligand Interactions by Automated Hydrogen/Deuterium Exchange Mass Spectrometry, Analytical Chemistry, 78 (4), 1005-1014. [Pg.71]

W. Burkitt and G. O Connor. (2008) Assessment of the Repeatability and Reproducibdity of Hydrogen/ Deuterium Exchange Mass Spectrometry Measurements, Rapid Communications in Mass Spectrometry, 22(23), 3893-3901. [Pg.71]

J. D. Venable, L. Okach, S. Agarwalla and A. Brock. (2012) Subzero Temperature Chromatography for Reduced Back-Exchange and Improved Dynamic Range in Amide Hydrogen/Deuterium Exchange Mass Spectrometry, Ana/ytica/ Chemistry, 84 (21), 9601-9608. [Pg.72]

Liu, Y.H., Konermann, L. (2006) Enzyme conformational dynamics during catalysis and in the resting state monitored by hydrogen/deuterium exchange mass spectrometry. FEBS Letters, 580 (22), 5137-5142. [Pg.90]

Khanal, A., Pan, Y., Brown, L.S., Konermann, L. (2012) Pulsed hydrogen/deuterium exchange mass spectrometry for time-resolved membrane protein folding studies. Journal of Mass Spectrometry, 47 (12), 1620-1626. [Pg.90]

Rey, M., Man, P., Brandolin, G., et at. (2009) Recombinant immobilized rhizopuspepsin as a new tool for protein digestion in hydrogen/deuterium exchange mass spectrometry. Rapid Communications in Mass Spectrometry, 23 (21), 3431-3438. [Pg.105]

Rey, M., Yang, M.L., Bums, K.M., et al. (2013) Nepenthesin from monkey cups for hydrogen/deuterium exchange mass spectrometry. Molecular and Cellular Proteomics, 12 (2), 464-472. [Pg.105]

Kadek, A., Mrazek, H., Halada, P, et al. (2014) Novel aspartic protease nepenthesin-1 as a tool for digestion in hydrogen/deuterium exchange mass spectrometry. Arwlytical Chemistry, 86 (9), 4287-4294. [Pg.105]

Seger, S.T., Breinholt, J., Faber, J.H., et al. (2015) Probing the conformational and functional consequences of disulfide bond engineering in growth hormone by hydrogen-deuterium exchange mass spectrometry coupled to electron transfer dissociation. Anal Chem, 87 (12), 5973-5980. [Pg.147]

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