Enhancing inflammation

Echchannaoui, H., et al., Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation, J. Infect. Dis. 186, 6, 798, 2002. 

Apparently the content of the active metabolite pyridoxamine S -phosphalc is lower in human than in mouse or hamster skin.120 When inflammatory response was assessed in a pyridoxine or riboflavin deficient rat model, data suggested enhanced inflammation in pyridoxine but not riboflavin... 

The ability of aspirin to diminish inflammation is apparently due to its inhibition of the synthesis of prostaglandins, a group of C-20 molecules that enhance inflammation. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group of the enzyme. 

Weinger JG, Brosnan CE, Loudig O, Goldbeig ME, Macian F, Arnett HAS, Prieto AL, Tsiperson V, Shafit-Zagardo B. Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis. J Neuroinflammation. 2011 8 49. doi 10. 1186/1742-2094-8-49. 

Carotenoids astaxanthin beta-carotene canthaxanthin lutein zeaxanthin Chlorella sp. Dunaliella salina Haematococcus pluvialis Spirulina sp. antioxidant properties cancer prevention cardiovascular protection DNA damage protection eye and skin protection glycation inhibition immune system enhancement inflammation prevention neuroprotection 53, 54... 

Fatty acids arachidonic acid docosahexaenoic acid eicosapentaenoic acid oleic acid Botryococcus braunii Chlorella sp. Crypthecodinium cohnii Nitzschia sp. Schizochytrium sp. cancer prevention cardiovascular protection immune system enhancement inflammation prevention mental and visual strengthening 56, 57... 

The role of platelet activation in initiation and propagation of coagulation is well studied. More recently, it has been demonstrated that activated platelets serve as a hub in thromboinflammation, in that they are linked to activation of the complement system by various mechanisms as well as to activation of the contact/kallikrein system. In both cases, these interactions lead to enhanced inflammation, suggesting that the platelet functions as an innate immune cell [7]. 

Inflammatory responses Immunotoxic mechanisms production and modulation of proinflammatory cytokines with ROS overproduction Enhanced inflammation and tissue damage where immune cell mobilization occurs Pb in rat brain produces neutrophil-derived inflammation and apoptosis Chetty et al. (2005), Kibayashi et al. (2010)... 

Suggestive evidence exists that some inorganic nanopartides can be translocated from the nasal area via the olfactory nerve to the central nervous system [26]. There, they might induce enhanced inflammation [26]. There is also some evidence that... 

Whether or not increased intake of n-6 fatty acids can exacerbate inflammation via increased production of proinflammatory eicosanoids remains uncertain. Results of in vitro studies and intervention studies in humans are generally consistent with this theoretical potential of n-6 fatty acids to enhance inflammation, at least in comparison to n-3 fatty acids and probably n-9 monounsaturated fatty acids. The importance of absolute and relative intakes of n-6 fatty acids to inflammatory processes also remains unclear. The effects of changes in n-6 fatty acid intake on inflammatory processes may depend on the background dietary fatty acid intake, as well as proportional and absolute intake of n-3 fatty acids. 

The prolonged effects of particulate air pollution measures on mortality imply that higher exposures could accelerate the occurrence of the disease and contribute to a more severe clinical picture. Enhanced inflammation in the airways and alveoli is a potential mechanism underlying these assoeiations. 

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