Enhancement strategies

The absorption-based platforms described previously employed evanescent wave interrogation of a thin sensing layer coated onto a planar waveguide. A sensitivity enhancement strategy for optical absorption-based sensors based on planar, multimode waveguides was developed recently by us18. The objective was to apply this theory to the development of low-cost, robust and potentially mass-producible sensor platforms and the following section outlines the assumptions and predictions of this theoretical model. 

Figure 6. Optical absorption-based sensor platform under consideration for enhancement strategy.

An important aspect of this enhancement strategy is its compatibility with current fabrication techniques, in particular polymer processing technology. The technique of micro-injection moulding was employed to produce polystyrene chips with an integrated array of cone structures intended for use in an aqueous environment. 

Some common throughput enhancement strategies for environmental samples are given in Table 2.5 (for details, see Ref. [38]). 

Optimization of Formulation Parameters and Drug Absorption Enhancement Strategies... 

Agu RU, Vu Dang H, Jorissen M, Willems T, Kinget R, Verbeke N (2002) Nasal absorption enhancement strategies for therapeutic peptides an in vitro study using cultured human nasal epithelium. Int J Pharm 237 179-191. 

Evaluation of absorption enhancing strategies on a mechanistic basis... 

In situ intestinal mechanisms (e.g., polarity in transport) Evaluation of absorption enhancing strategies on a mechanistic basis Well-defined absorptive area Good oxygenation Closest model to in vivo Implies anesthesia and surgery... 

This chapter focuses on rectal drug administration, which represents one of the most common routes of transmucosal drug delivery, and some aspects of rectal drug absorption, including enhancement strategies. 

THE CHOLINERGIC HYPOTHESIS OF ALZHEIMER S DISEASE AND CHOLINERGIC ENHANCEMENT STRATEGIES... 

Six Sigma A quality enhancement strategy designed to reduce the number of products coming from a manufacturing plant that do not conform to... 

The objective of this book is to provide an up-to-date and critical evaluation of the application of biophysical tools and analysis for the determination of molecular transport across the skin. Both the nature of the passive permeability barrier and the impact of diverse penetration enhancement strategies are considered and discussed. 

Hadgraft, J. Passive enhancement strategies in topical and transdermal drug delivery. Int. J. Pharm. 1999,184, 1-6. 

Tissue-based systems evaluation of transport mechanism segmental absorption evaluation evaluation of absorption enhancing strategies other tissues (nasal, buccal) comparison between species possible presence of nerves (e.g., local control, crypt-villus axis) transporters and enzymes as in vivo limited database viability of tissue low throughput limited access to (human) tissue... 

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