Effusion lymphoma

Curcumin was found to inhibit cellular proliferation and enhance apoptosis in a variety of lymphoma cell lines in vitro [Skommer et al., 2006 Thompson et al., 2004 Wu et al., 2002]. The proposed mechanism of curcumin s action in the majority of these studies involves the suppression of the expression of NF-KB-regulated gene products. One study suggested a novel function for curcumin as a suppressor of JAK-1 and STAT3 activation in primary effusion lymphoma cells, a function that would lead to the inhibition of proliferation and the induction of caspase-dependent apoptosis [Uddin et al., 2005],... 

Uddin S, Hussain AR, Manogaran PS, Al-Hussein K, Platanias LC, Gutierrez MI, Bhatia KG. 2005. Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma. Oncogene 24 7022-7030. 

Cesarman E, Knowles DM. Kaposi s sarcoma-associated herpesvirus a lymphotropic human herpesvirus associated with Kaposi s sarcoma, primary effusion lymphoma, and multicentric Castleman s disease. Semin Diagn Pathol 1997 14 54-66. 

Katano H, Sato Y, Kurata T, et al. Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi s sarcoma, and multicentric Castleman s disease. Virology. 2000 269 335-344. 

Ely SA, Powers J, Lewis D, et al. Kaposi s sarcoma-associated herpesvirus-positive primary effusion lymphoma arising in the subarachnoid space. Hum Pathol. 1999 30 981-984. 

Said JW, Shintaku IP, Asou H, et al. Herpesvirus 8 inclusions in primary effusion lymphoma report of a unique case with T-cell phenotype. Archiv Pathol Lab Med. 1999 123 257-260. 

BL, Burkitt lymphoma BLL, Burkitt-like lymphoma cHL, classical Hodgkin lymphoma IL, immunoblastic lymphoma LBL-B, lymphoblastic lymphoma precursor B-cell LBL-T, lymphoblastic lymphoma precursor T-cell LPL, lymphoplasmacytic lymphoma MM, multiple myeloma N, almost always negative PCLBL, primary cutaneous large B-cell lymphoma PEL, primary effusion lymphoma pHL, lymphocyte predominance Hodgkin lymphoma P-PTLD, polymorphic posttransplant lymphoproliferative disorders P-TCL, peripheral T-cell lymphoma PTLD, posttransplant lymphoproliferative disorders. 

PRIMARY EFFUSION LYMPHOMA " A neoplasm induced by human herpes virus 8 (Kaposi s sarcoma-associated... 

Nador RG, Cesarman E, Chadburn A, et al. Primary effusion lymphoma a distinct clinicopathologic entity associated with the Kaposi s sarcoma-associated herpes virus. Blood. 1996 88(2) 645-656. 

Several rare lymphomas exist in the lung. The most notable is lymphomatoid granulomatosis. Other rare lymphomas include intravascular lymphoma, primary effusion lymphoma, pyothorax-associated lymphoma, secondary lymphomas/leukemias, and Erdheim-Chester syndrome. 

Banks PM, Warnke RA. Primary effusion lymphoma. In WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Lyon lARC Press 2001 179-180. 

Pre-T-ALL, primary effusion lymphoma, types of B-cell lymphoma... 

Primary effusion lymphoma, thyroid carcinoma, breast carcinoma, adrenal cortical tumors, keratoacanthomaO... 

The HHV-8 virus is found in association with Kaposi s sarcoma, rare forms of B-cell lymphoma, multiple myeloma, primary effusion lymphoma, Castleman s disease and sarcoidosis. HHV-8 has been detected in the majority of bone marrow samples taken from multiple myeloma patients. Recently HHV-8 was described in association with the pulmonary and extrapulmonary inflammatory pseudotumor (inflammatory myoflbroblastic tumor). 

Hussain, A.R., N. A. Al-Jomah, A.K. Siraj, et al. 2007. Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells. Cancer Res. 67(8) 3888-3897. 

Liu C. Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV- 8-infected primary-effusion lymphoma cell lines and mediate VEGF- independent antiapoptotic effects. J Virol 2001 75(22) 10933-40. 

Gottwein E, Corcoran DL, Mukheijee N, Skalsky RL, Hafner M, Nusbaum JD, Shamulailatpam P, Love CL, Dave SS, Tuschl T, Ohler U, Cullen BR. Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines. Cell Host Microbe. 2011 10 515-26. 

Matolcsy A, NMor RG, Cesarman E, Knowles DM. Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation. Am J Pathol. 1998 153 1609-14. 

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