Toxicological effects

Bala, S., Weaver, J., and Hastings, K.L., Clinical relevance of preclinical testing for allergic side effects, Toxicology, 209, 195, 2005. 

Berger ML, Sozeri T. 1987. Rapid halogenated hydrocarbon toxicity in isolated hepatocytes as mediated by direct solvent effects. Toxicology 45 319-330. 

The term repeated dose toxicity comprises the adverse general (i.e., excluding reproductive, genotoxic, or carcinogenic effects) toxicological effects occurring as a result of repeated daily dosing with, or exposure to, a substance for a part of the expected life span (subacute or subchronic exposure) or for the major part of the fife span, in case of chronic exposure (EC 2003). 

Cleuvers M. (2003). Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicology Letters 142 185-194. 

Provides toxicology data for more than 130,000 chemicals in four categories substance identification toxicity/biomedical effects toxicology and carcinogenicity review and exposure standards and regulations. Built and maintained by the National Institute for Occupational Safety and Health (NIOSH) as a segment of the Toxic Release Inventory database. Available online, CD-ROM and computer tape from NIOSH and from commercial database vendors. 

Emergency overview Regulatory status Potential health effects Toxicological Information... 

Soderlund DM, Clark JM, Sheets LP, et al. Mechanisms of pyrethroid neurotoxicity Implications for cumulative risk effect. Toxicology 2002 171(1) 3-59. 

Warner A. Cost-effective toxicology testing, In-Service Training and Continuing Education, American Association for Clinical Chemistry 1996 17(2) February. 

Hussain I, Piepenbriuk M, Fitch KJ, Marsh JA, Dietert RR. Developmental immunotoxicity of cyclosporin-A in rats age-associated differential effects.Toxicology 2005 206 273-284. 

Hallgren S, Damerud PO (2002) Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats testing interactions and mechanisms for thyroid hormone effects. Toxicology 177 227-243... 

Case reports and summaries No centralized record of recipients Toxicological studies of effects Toxicological studies of interactions No centralized database of recipients Amount shipped to theater No industrial hygiene monitoring data... 

Wangikar, P.B., Dwivedi, P., Sinha, N., Sharma, A.K. Telang, A.G. (2005) Teratogenic effects in rabbits of simultaneous exposure to ochratoxin A and aflatoxin B(1) with special reference to microscopic effects. Toxicology 215, 37-47. 

The SDS contains information on the identity of the substance or the mixture, potential health effects, toxicological properties, physical hazards, safe use, handling and storage, emergency procedures, and disposal requirements specific to the chemical (see Fig. 26.2). Intermediate products are to be considered as mixtures of substances. 

Individual PCB congeners differ by their biological effects. Toxicological studies have shown that some congeners act by the same mechanisms as polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF), whose toxicity is mediated by interaction with a protein receptor. Other PCBs act by totally different mechanisms. 

P.H. Roos, S. Tschirbs, F. Pfeifer, et al.. Risk potentials for humans or original and remedicated PAH-contaminated sods application of biomarkers of effect. Toxicology 205 (3) (2004) 181-194. 

E.V. Hess, Environmental chemicals and autoimmune disease cause and effect. Toxicology 181-182 (2002) 65-70. 

Roos, P.H. Tschirbsa, S. Pfeifer, F. Welge, P. Hack, A. Wilhelm, M. Bolt, H.M. 2004. Risk potencials for humans of original and remediated PAH-contaminated soils application of biomarkers of effect. Toxicology, v. 205, p.181-194. 

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