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Developmental immunotoxicity

As was the case with tier testing, developmental immunotoxicology has been driven by expert workshops to reach consensus on the most important issues three workshops were held in 2001 [79-81], and another in 2003 [82], These workshops contributed to the development of a proposed testing framework to detect developmental immunotoxicity, which is described in detail in chapter 21. [Pg.12]

Luster, M.I., Dean, J.H. andGermolec, D.R., Consensus workshop on methods to evaluate developmental immunotoxicity, Environ. Health Perspect., Ill, 579, 2003. [Pg.19]

Bunn, T.L. et al., Gender-based profiles of developmental immunotoxicity to lead in the rat Assessment in juveniles and adults, J. Toxicol. Environ. Health Part A 64, 101, 2001. [Pg.221]

Immune Function Assays Used in Developmental Immunotoxicity Testing..334... [Pg.327]

A recent workshop18 and forum19 addressed issues of the appropriate immune function methods and rodent species for evaluating developmental immunotoxicity. In both meetings the rat was identified as the preferred animal model for developmental immunotoxicity testing. This chapter will review evidence which implicates certain chemicals and drugs as being developmental immunotoxicants in rodents. [Pg.328]

IMMUNE FUNCTION ASSAYS EMPLOYED IN DEVELOPMENTAL IMMUNOTOXICITY TESTING... [Pg.334]

More recently, the National Institute of Environmental Health Sciences and the National Institute for Occupational Safety and Health convened a workshop in which experts in the field of developmental immunotoxicology developed a tiered approach for assaying the developmental immunotoxicity of chemicals.18 The recommended assays were separated into three groups (1) an initial set of screening assays, (2) assays for validation of a correlation between the assay end point and functional outcomes in humans, and (3) assays for research development.18 The initial screening assays included analysis of the primary antibody response to a T-dependent antigen, the delayed type... [Pg.334]

A variety of compounds have been evaluated for developmental immunotoxicity. Early work with chlorinated hydrocarbon insecticides revealed that lactating women exposed to the insecticide chlordane, had residues of chlordane in their breast milk.97 A study was performed in mice to determine if chlordane might alter the immune system of mouse pups exposed to chlordane via the dam s milk.98 Female pups displayed... [Pg.335]

The chemicals examined for developmental immunotoxicity in the mouse and rat encompasses a range of classes that include metals, pesticides, drugs, and aromatic hydrocarbons. Suppression of immune function was observed in adult rodents exposed to each of these chemicals during immune system development. The duration of immune function suppression in rodents so exposed ranged from 3 weeks (i.e., DOTC and MXC) to 19 months (i.e., TCDD) after the last exposure to the chemical. [Pg.338]

Neubert, R.T., Webb, J.R. and Neubert, D. Feasibility of human trials to assess developmental immunotoxicity, and some comparison with data on New World monkeys. Human Exper. Toxicol., 21(9-10), 543, 2002. [Pg.360]

Holsapple, M.P. Developmental immunotoxicity testing A review. Toxicology, 185, 193, 2003. [Pg.361]

Bunn, T.L., Ladies, G.S., Holsapple, M.P., and Dietert, R.R. Developmental immunotoxicity assessment in the rat Age, gender, and strain comparisons after exposure to lead. Toxicol. Methods, 11,41, 2001. [Pg.361]

Vaccines may have the potential to cause immunotoxicty (10). The immature immune system of the child may be more sensitive to such effects than that of the adult (II). Developmental immunotoxicity may result, for instance, in a persistent immune depression or a skewed balance between the innate and acquired... [Pg.86]

Dietert RR, DeWitt J (2010) Developmental immunotoxicity (DIT) the why, when and how of DIT testing. In Dietert RR (ed) Immunotoxicity testing methods and protocols. Humana Press, New York, pp 17-26... [Pg.89]

Developmental immunotoxicity of methybnercury the relative sensitivity of developmental and immune parameters. Toxicol Sci 117(2) 325-335... [Pg.340]

Developmental immunotoxicity of di-n-octyltin dichloride (DOTC) in an extended one-generation reproductive toxicity study. Toxicol Lett 204(2-3) 156-163... [Pg.340]

See other pages where Developmental immunotoxicity is mentioned: [Pg.18]    [Pg.54]    [Pg.216]    [Pg.221]    [Pg.221]    [Pg.328]    [Pg.328]    [Pg.334]    [Pg.336]    [Pg.341]    [Pg.347]    [Pg.349]    [Pg.351]    [Pg.353]    [Pg.355]    [Pg.355]    [Pg.357]    [Pg.359]    [Pg.361]    [Pg.361]    [Pg.373]    [Pg.261]    [Pg.453]    [Pg.86]    [Pg.329]   
See also in sourсe #XX -- [ Pg.86 , Pg.329 ]



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