Edema during pregnancy

Indications Spleen vacuity/liver depression, damp turbidity pouring downward. Abnormal vaginal discharge, hemophilus vaginitis, vulvitis, cervical inflammation, diarrhea, edema during pregnancy, edema during menstruation, and headache... 

Sodium is contraindicated in patients with hypernatremia, fluid retention, and when the administration of sodium or chloride could be detrimental. Sodium is used cautiously in surgical patients and those with circulatory insufficiency, hypoproteinemia, urinaiy tract obstruction, congestive heart failure, edema, and renal impairment. Sodium is a Pregnancy Category C drug and is used cautiously during pregnancy. 

Diuretics have been used for the treatment of both hypertension and edema in pregnancy. While regimens including thiazides have improved the outcome in hypertension developing during the first 20 weeks of pregnancy, the situation in later pregnancy seems to be different. Some controlled studies have shown that the thiazides do not... 

Indications Plum pit qi. Neurotic esophageal stenosis, globus hystericus, gastrointestinal neurosis, chronic laryngitis, tracheitis, neurasthenia, morning sickness, bronchitis, hysteria, neurosis, recurrent palpitations, asthma, pertussis, toxemia during pregnancy, and edema... 

Other Diseases. These included diabetes, scarlet fever, diphtheria, influenza, pulmonary tuberculosis, heart diseases (palpitation, edema, intermittency of pulse), disorders of respiration, asthma, hay fever, bronchitis, pneumonia, morning sickness during pregnancy, diarrhea, chronic gastritis, chronic rheumatism, eye inflammation, scrofula, leukemia, breast and other cancers, high blood pressure, bites of snakes and rabid animals, passive dropsies, as an abortifacient, and so on and so on. 

In normal pregnancy there is hypouricemia during the first months, with an increase to slightly above the normal near term (Resen Steenstrup, 1956). Mull and Bill (1945) likewise described a hypouricemia in pregnancy. Munro Kerr et al. (1948) noted that the levels of uric acid in toxemia of pregnancy are increased in the absence of severe kidney injury. Similar observations were made by Lindeboom (1947) in eclampsia. Mukherjee and Govan (1950) reported an elevated level of uric acid in the tissue fluid in the edema of pregnancy in comparison with the tissue fluid of healthy mothers at term. 

Another condition that can impair venous return is pregnancy. As the uterus enlarges during gestation, it may cause compression of the veins draining the lower extremities. Once again, venous and capillary pressures are increased. Filtration is enhanced, reabsorption is inhibited, and edema develops in the lower extremities. 

Pregnant women should be advised to contact their physician before taking spironolactone, since routine use of diuretics during normal pregnancy is inappropriate and exposes the mother and her fetus to an unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of toxemia. Diuretics are indicated only in the treatment of edema due to pathologic causes, or as a short course of treatment in patients with severe hypervolemia. 

The thiazolidinedion are contraindicated in patients witii a hypersensitivity to the drug or any component of the drug and severe heart failure. These dni are Pregnancy Category C dru and should not be used during pr nancy unless tiie potential benefit of therapy outweighs the potential risk to the fetus. The thiazolidinediones are used cautiously in patients witii edema, cardiovascular disease, and liver or kidney disease. Th e dru may alter the effects of oral contraceptive. 

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