Morning sickness

One enantiomer of penicillamine (D-) exhibits antiarthritic properties but foe other is highly toxic (Figure 8.3). The teratogenic effects of thalidomide were induced by one enantiomer, foe other exhibited foe beneficial effects against morning sickness. 

Several histamine receptor antagonists are effective in treating motion sickness, Meniere s disease, morning sickness, uraemia and postoperative vomiting. They are not effective against cytotoxics. Antagonists with... 

Pyridoxine is used in morning sickness. Its mechanism of action remains unclear and several reviews of the use of pyridoxine have failed to find conclusive evidence of effectiveness. A recent double blind trial found pyridoxine to be of benefit in reducing nausea only. Some clinicians use pyridoxine as the first drug on the basis that it is the least likely to be toxic to the foetus. 

Thalidomide used to alleviate the symptoms of morning sickness in pregnant women before 1963. 

You may have heard of the thalidomide tragedy. Thalidomide was widely prescribed to pregnant women in the 1950s and early 1960s as a drug to combat morning sickness. Tragically, many of the babies born to these women had malformed limbs and it was later proved that thalidomide was linked to these birth defects. 

The drug was administered as a racemic mixture both optical isomers were present in equal proportions. The isomer labelled R prevented morning sickness, whereas the isomer labelled S caused birth defects. 

Like fluorochlorobromomethane, thalidomide exists in right-handed and left-handed forms. Thalidomide as marketed contained equal amounts of both forms. As was learned later, the beneficial effect for pregnant women is mostly due to one of these forms. The potential to cause birth defects is largely due to the other. However, thalidomide would have been a hopeless case for morning sickness even if the marketed drug contained only the good molecule. The two enantiomers of thalidomide are interconverted in vivo. Any threat to the ferns is unacceptable. 

Pregnancy is a common cause of early morning vomiting. The condition is referred to as morning sickness and may be relieved by taking dry biscuits on waking up. 

As an antiemetic in drug and disease induced vomiting. Also useful in morning sickness but are ineffective in motion sickness. 

It is indicated to prevent and treat isoniazid, hydralazine, penicillamine and cycloserine induced neurological disturbances, mental symptoms in women on oral contraceptives, pyridoxine responsive anaemia and homocystinuria, morning sickness and hyperemesis gravidarum, convulsions in infants and children. 

Ginger 20 27.48 million (7) Chemotherapy-induced nausea, morning sickness, postoperative nausea and vomiting, vertigo Motion sickness... 

Recurrent colds, spontaneous sweating with slight fever and aversion to wind after illness, surgery or childbirth, chronic sinusitis, allergies, and morning sickness in early pregnancy. 

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