Echothiophate iodide

Powders for Reconstitution. Drugs that have only limited stability in liquid form are prepared as sterile powders for reconstitution by the pharmacist prior to dispensing to the patient. In ophthalmology, these drugs include a-chymotrypsin, echothiophate iodide... [Pg.456]

L The answer is b. (Hardman, pp 166-167.) Echothiophate iodide is a long-acting (irreversible) cholinesterase inhibitor. It is used topically in the eye for the treatment of various types of glaucoma. Maximum reduction of intraocular pressure occurs within 24 h, and the effect may persist for several days. The drug is a water-soluble compound, which affords it a practical advantage over the lip id-soluble isofluorphate (another cholinesterase inhibitor used to treat glaucoma). [Pg.184]

Diphenhydramine hydrochloride, 3,173 Diphenoxylate hydrochloride, 7,149 Disulflram, 4, 168 Dobutamine hydrochloride, 8,139 Droperidol, 7,171 Echothiophate iodide, 3,233 Epinephrine, 7, 193 Ergotamine tartrate, 6,113 Erythromycin, 8,139 Erythromycin estolate, 1, 101 2, 573 Estradiol valerate, 4,192 Ethambutol hydrochloride, 7,231 Ethynodiol diacetate, 3,253 Fenoprofen calcium, 6,161 Flucytosine, 5,115 Fludrocortisone acetate, 3, 281 Fluorouracil, 2,221 Fluoxymesterone, 7,251 Fluphenazine enanthate, 2, 245 4,523 Fluphenazine hydrochloride, 2,263 4,518 Gluthethimide,5,139 Gramicidin, 8,179 Griseofulvin, 8,219 Halcinonide, 8,251 Halothane, 1, 119 2,573 Hexetidine, 7,277 Hydralazine hydrochloride, 8,283 Hydroflumethiazide, 7,297 Hydroxyprogesterone caproate, 4,209 Hydroxyzine dihydrochloride, 7,319 Iodipamide, 3,333 Isocarboxazid, 2, 295... [Pg.557]

Lehman, R.A., and Nicholls, M.E. Antagonism of phosphollne (echothiophate) iodide by certain quaternary oximes. Proc. Soc. Exp. Biol. Med. 104 550-554, i960. [Pg.42]

Synonyms. Diethoxyphosphinylthiocholine Iodide Echothio-pate Iodide Echothiophate Iodide Ecostigmine Iodide. Proprietary Names. Echodide Phospholine Iodide Phospho-linjodid. [Pg.579]

Ecgonine, 385, 490, 579 Ecgonine benzoate, 385 Echodide, 579 Echothiopate iodide, 579 Echothiophate iodide, 579 Eclipse, 847 Econacort, 579 Econal, 531, 1040 Econazole, 579 Econazole nitrate, 579 Econochlor, 443 Econocil VK, 888 Econopred, 917... [Pg.1340]

Echothiophate iodide 0.25 Most cells normal some cells showed loss of microvilli and... [Pg.29]

The clinically useful anticholinesterase agents diisopropyl fluorophosphate (DFP, Floropryl) and echothiophate iodide (Phospholine Iodide [PI]) demonstrate an indirect-acting mechanism resulting in increased levels of acetylcholine at the cholinergic receptor sites. The inhibition of acetylcholinesterase produces a relatively long-lasting and irreversible effect of maintaining active levels of acetylcholine at the parasympathetic synapses. [Pg.666]

Echothiophate Iodide for Ophthalmic Solution Glass, 1.8 M X 2mm I.D. silanised S3 (80-100 mesh) Helium 115 TCD Anhydrous Methanol USP (24, p. 621)... [Pg.497]

There are few, if any, indications for the therapeutic use of miotics in the horse. However, a 2% solution of the parasympathomimetic agent pilocarpine can induce miosis in normal eyes after repeated topical application (van der Woerdt et al 1998). The cholinesterase irihibitor topical miotics, including demecarium bromide and echothiophate iodide, appear to be potentially uveitogenic in the horse and should not be used. [Pg.241]

Echothiophate todide, U5P. Echothiophate iodide. (2-mcreaptoethyDtrimethylammonium iodide. S-ester with O,0-dicthylphosphoroihioate (Phospholine Iodide), occurs as a white, crystalline. hygro.scopic solid that has a slight mercaptan-like odor. It is soluble in water (1 1) and dehydrated alcohol (l 2S) aqueous. solutions have a pH of about 4 and are stable at room temperature for about I month. [Pg.569]

Echothiophate iodide is a long-lasting cholinesterase inhibitor of the irreversible type, as is isofluorphate. Unlike the latter, however, it is a quaternary salt, and when applied locally, its distribution in tissues is limited, which can be very de.sirablc. It is used as a long-acting anticholinesterase agent in the treatment of glaucoma. [Pg.569]

Acetylcholine Cl (Miochol) Carbachol intraocular (Miostat) Pilocarpine HCL (Isopto Carpine) Pilocarpine nitrate (Ocusert Pilo-20) Echothiophate iodide (Phospholine Iodide) Physostigmine salicylate (Isopto Eserine) Betaxolol HC1 (Betoptic) Levobunolol HC1 Timolol maleate (Timoptic) Acetazolamide (Diamox) Brinzolamide ophthalmic sus. 1% Dichlorphenamide (Daranide) Dorzolamide (Trusopt) Methazolamide (Neptazane)... [Pg.346]

Medscape Drug Reference. (2006), Echothiophate Iodide Opht. New York, NY, WebMD. Last viewed October 10, 2006, http /www.medscape.com/druginfo... [Pg.710]

Fig. 4. Effect of 1 /ig/ml hemicholinium-3 applied topically on cortical ACh output and content without or with the previous topical application of echothiophate iodide in pretrigeminally sectioned non-anaesthetised cats. A, ACh output B, ACh content without echothiophate and C, ACh content following the application for 30 min of 0.5 mg/ml echothiophate iodide. (Reproduced from Can. J.

ECHOTHIOPHATE IODIDE (Phospholine Iodide powder for reconstitution 6.25 mg to make 0.125%)... [Pg.219]

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