Hydroxyprogesterone caproate

15% hydrochloric acid, 10% sodium bicarbonate and finally water. The solvent was stripped off. The residual oil was mixed with 300 ml of 28% aqueous ammonia for 1 hour. The ammonia and water were vacuum distilled at a temperature of 40°C or less. Then 300 cc of carbon tetrachloride was added and the solution dried with sodium sulfate. The solution was cooled at 0°C and then filtered. The crystals were washed with cold carbon tetrachloride and vacuum dried. The yield was 57 g of dried product having a melting point of 55°C to 56.5°C. 

Sifferd, R.H. and Braitberg, L.D. U.S. Patent 3,066,164 November 27, 1962 assigned to Armour Pharmaceutical 

Trade Name Manufacturer Country Year Introduced 

Caproic acid anhydride Hydrogen chloride Cyclohexanone 

By oxidation in 100 cc of absolute toluol with 425 cc of cyclohexanone and 155 cc of a 20% aluminum isopropylate solution in absolute toluol and after repeated crystallizations from isopropyl ether or methanol, 24 grams of pure 17o-oxyprogesterone-17-caproate is obtained, MP 119° to 121°C (dense needles). 

Chemical Name 17-[(1-oxohexyl)oxy] pregn-4-ene-3,20-dione Common Name — 

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In a modification of this scheme, hydroxypregnenolone is first acetylated under mild conditions to the 3-acetate and then under forcing conditions with caproic anhydride to give the acetate-caproate (122). Ester interchange with methanol removes the acetate at 3 Oppenauer oxidation affords hydroxyprogesterone caproate (124). ... 

Hydroxyprogesterone caproate Cyclohexylacetone Droprenilamine HCl Propylhexedrine Cyclohexylamine Clorexolone Cyclamate calcium 1 -Cyclohexylamino-2-propanol Hexylcaine HCl Cyclohexyl bromide Cetiedll... 

C21H30O3 68-96-2) see Chlormadinone acetate Cyproterone acetate Hydroxyprogesterone caproate Medroxyprogesterone acetate 1 la-hydroxy progesterone... 

Diphenhydramine hydrochloride, 3,173 Diphenoxylate hydrochloride, 7,149 Disulflram, 4, 168 Dobutamine hydrochloride, 8,139 Droperidol, 7,171 Echothiophate iodide, 3,233 Epinephrine, 7, 193 Ergotamine tartrate, 6,113 Erythromycin, 8,139 Erythromycin estolate, 1, 101 2, 573 Estradiol valerate, 4,192 Ethambutol hydrochloride, 7,231 Ethynodiol diacetate, 3,253 Fenoprofen calcium, 6,161 Flucytosine, 5,115 Fludrocortisone acetate, 3, 281 Fluorouracil, 2,221 Fluoxymesterone, 7,251 Fluphenazine enanthate, 2, 245 4,523 Fluphenazine hydrochloride, 2,263 4,518 Gluthethimide,5,139 Gramicidin, 8,179 Griseofulvin, 8,219 Halcinonide, 8,251 Halothane, 1, 119 2,573 Hexetidine, 7,277 Hydralazine hydrochloride, 8,283 Hydroflumethiazide, 7,297 Hydroxyprogesterone caproate, 4,209 Hydroxyzine dihydrochloride, 7,319 Iodipamide, 3,333 Isocarboxazid, 2, 295... 

Hydromorphone Hydroxocobalamin Hydroxychloroquine Hydroxyethyl starch Hydroxyprogesterone caproate Hyoscyamine sulfate... 

Progestins, steroid compounds similar to progesterone, such as hydroxyprogesterone caproate (28.3.6), medroxyprogesterone acetate (28.3.7), and megestrol acetate (28.3.7), are used for palliative treatment of breast carcinomas and renal tumors. Progestins can have a direct local effect on cells, and can simultaneously lower the quantity of leutenizing hormone. 

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