Phospholine iodide

Ecostatin, Gyno-Pevaryl Phospholine Iodide Vasotec, Xanef Ethrane... 

Echothiophate is a phosphorylthiocholine with pharmacological action analogous to that of isofluorophate however, spontaneous reduction of phosphorylated enzyme occurs faster after using isofluorophate. It is used in various forms of glaucoma. Synonyms of this drag are echodide and phospholine iodide. 

Quaternary compounds (substituted ammonium salts, methacholine chloride, mepenzolate bromide, phospholine iodide, etc.) approximately 10%... 

Synonyms. Diethoxyphosphinylthiocholine Iodide Echothio-pate Iodide Echothiophate Iodide Ecostigmine Iodide. Proprietary Names. Echodide Phospholine Iodide Phospho-linjodid. 

The clinically useful anticholinesterase agents diisopropyl fluorophosphate (DFP, Floropryl) and echothiophate iodide (Phospholine Iodide [PI]) demonstrate an indirect-acting mechanism resulting in increased levels of acetylcholine at the cholinergic receptor sites. The inhibition of acetylcholinesterase produces a relatively long-lasting and irreversible effect of maintaining active levels of acetylcholine at the parasympathetic synapses. 

Echothiophate todide, U5P. Echothiophate iodide. (2-mcreaptoethyDtrimethylammonium iodide. S-ester with O,0-dicthylphosphoroihioate (Phospholine Iodide), occurs as a white, crystalline. hygro.scopic solid that has a slight mercaptan-like odor. It is soluble in water (1 1) and dehydrated alcohol (l 2S) aqueous. solutions have a pH of about 4 and are stable at room temperature for about I month. 

Ecostatin econazolenitrate, ecothiopate ecothiopate iodide, ecothiopate iodide [ban, inn] (echothiopate diethoxyphosphinylthiocholine Ml 217 Camsilon Phospholine Iodide ) is an irreversible (organophosphate group) ANTICHOLINESTERASE. It is a PARASYMPATHOMIMETIC used topically as a miotic in ANTIGLAUCOMA TREATMENT. 

Phospholine Iodide" - ecothiopate iodide. PHOSPHOLIPASE INHIBITORS act at sites on phospholipases, a large group of enzymes with many roles. There are two main groups of enzyme of particular interest in relation to receptor signalling, which makes them important drug targets phospholipase Aj and phospholipase C. These will be discussed in turn. 

Acetylcholine Cl (Miochol) Carbachol intraocular (Miostat) Pilocarpine HCL (Isopto Carpine) Pilocarpine nitrate (Ocusert Pilo-20) Echothiophate iodide (Phospholine Iodide) Physostigmine salicylate (Isopto Eserine) Betaxolol HC1 (Betoptic) Levobunolol HC1 Timolol maleate (Timoptic) Acetazolamide (Diamox) Brinzolamide ophthalmic sus. 1% Dichlorphenamide (Daranide) Dorzolamide (Trusopt) Methazolamide (Neptazane)... 

Echothiophate Carbonic anhydrase Phospholine iodide Solution 0.125 Once or twice a day ... 

Topical miotic agents are historically important glaucoma medications but are less commonly used today. Miotics lower lOP by causing muscarinic-induced contraction of the ciliary muscle, which facilitates aqueous outflow. They do not affect aqueous production. Multiple miotic agents have been developed. Pilocarpine and carbachol are cholinomimetics that stimulate muscarinic receptors. Ecbotbiopbate (Phospholine iodide) is an organophosphate inhibitor of acetylcholinesterase it is relatively stable in aqueous solution and, by virtue of its quaternary ammonium structure, is positively charged and poorly absorbed. The usefulness of these medicines is lessened by their numerous side effects and the need to use them three to four times a day. 

ECHOTHIOPHATE IODIDE (Phospholine Iodide powder for reconstitution 6.25 mg to make 0.125%)... 

Echothiophate (phospholine iodide) 0.125% solution Glaucoma, accommodative esotropia Same as for physostigmine... 

Drance, S. M. (1969). The effects of phospholine iodide on the lens and anterior chamber depth. In Symposium on Ocular Therapy 0- H. Leopold. Ed,), pp. 25-31. Mosby, St. Louis. 

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