Fenoprofen calcium 42

Diphenhydramine hydrochloride, 3,173 Diphenoxylate hydrochloride, 7,149 Disulflram, 4, 168 Dobutamine hydrochloride, 8,139 Droperidol, 7,171 Echothiophate iodide, 3,233 Epinephrine, 7, 193 Ergotamine tartrate, 6,113 Erythromycin, 8,139 Erythromycin estolate, 1, 101 2, 573 Estradiol valerate, 4,192 Ethambutol hydrochloride, 7,231 Ethynodiol diacetate, 3,253 Fenoprofen calcium, 6,161 Flucytosine, 5,115 Fludrocortisone acetate, 3, 281 Fluorouracil, 2,221 Fluoxymesterone, 7,251 Fluphenazine enanthate, 2, 245 4,523 Fluphenazine hydrochloride, 2,263 4,518 Gluthethimide,5,139 Gramicidin, 8,179 Griseofulvin, 8,219 Halcinonide, 8,251 Halothane, 1, 119 2,573 Hexetidine, 7,277 Hydralazine hydrochloride, 8,283 Hydroflumethiazide, 7,297 Hydroxyprogesterone caproate, 4,209 Hydroxyzine dihydrochloride, 7,319 Iodipamide, 3,333 Isocarboxazid, 2, 295... 

Rades, T., Padmadisastra, Y., and Mueller-Goymann, C.C., Thermal behaviour and solubility of fenoprofen calcium, Pharmazie, 51 846-851 (1996). 

The API fenoprofen calcium is a diaryl ether. Degradation of fenopro-fen under intense ultraviolet light in solution yields a mixture of isomeric biphenyls via a photo-Fries rearrangement mechanism (Fig. 76) (117). 

Figure 76 Fenoprofen calcium photodegradation and proposed mechanism.

Infra-red Spectrum. Principal peaks at wavenumbers 1562,1225, 696,1211,1268,1248 (fenoprofen calcium, KBrdisk). 

Fluphenazine Hydrochloride 558.6 Fenoprofen Calcium 648.8 Physostigmine Sulphate... 

For therapeutic purposes, a similar frequently used group of drug compounds is the non-steroidal antiinflammatory drugs (NSAIDs). One of the best known representatives of the aryl acetic acid derivatives in diclofenac and that of aryl propionic acid derivatives ibuprofen. As both have acidic properties, they dissociate while being dissolved and may form salts with amphiphilic properties. Together with appropriate counterions, these amphiphilic organic acids may form lyotropic mesophases with water at even room or body temperature e.g., diclofenac diethylamine or ibuprofen lysinate. Furthermore, some anhy-drates of NSAID, e.g., fenoprofen calcium,exhibit thermotropic mesomorphism after thermal dehydration of the crystalline salt. 

Gall EP, Caperton EM, McComb JE, Messner R, Multz CV, O Hanlan M, Willkens RF. Clinical comparison of ibuprofen, fenoprofen calcium, naproxen and tolmetin sodium in rheumatoid arthritis. J Rherrmatol 1982 9(3) 402-7. 

Like the arylacetic acids the arylpropionic acid analogues also exhibit potent anti-inflammatory properties besides usual antipyretic and analgesic characteristics. A few examples of this category of compounds are discussed here, flurbiprofen ketoprofen indoprofen fenoprofen calcium. 

Fenoprofen calcium is indicated for treatment of rheumatoid arthritis and osteoarthritis and for the relief of mild to moderate pain. 

Acetylsalicylic Acid (ASA) Aspirin Celecoxib Celebrex Diclofenac sodium Voltaren Diflunisal Dolobid Etodolac Iodine Fenoprofen calcium Nalfon... 

Mullins JD, MacekTJ (1960). Some pharmaceutical properties of novobiocin. JAm Pharm Assoc 49 245. Nash JF etal. (1979). Linear pharmacokinetics of orally administered fenoprofen calcium. J Pharm Sci 68 1087-1090. 

Propionic acid derivatives Ibuprofen Naproxen Fenoprofen calcium Benoxaprofen... 

Curt, B.A., Kaldany, A., Whitley, L.G. et al. (1980). Reversible rapidly progressive renal failure with nephrotic syndrome due to fenoprofen calcium. Ann. Int. Med., 92, 72-73... 

Davis, ., Turner, R., Collins, R. and Kauf-mann,J. (1976) Comparison of fenoprofen calcium and aspirin therapy during gold induction in rheumatoid arthritis. Clin. Pharmacol. Ther., 19, 105. 

---