Eag channel

Ficker, E., Jarolimek, W. and Brown, A. M. (2001) Molecular determinants of inactivation and dofetilide block in efher-a-go-go (EAG) channels and EAG-related K+ channels. Molecular Pharmacology, 60, 1343-1348. 

Shaker-channels, eag (ether- -go-go)-channels, slo (slow-poke)-channels were cloned from behavioral Drosophila melanogaster mutants. The channels were named according to the Drosophila mutant phenotype, Shaker, ether-go-go, slow-poke. Subsequently, eag-cDNA was used to clone related voltage-gated potassium channel subunits erg (eag-related) and elk (eag-like). The human erg ortholog (HERG) mediates cardiac DCS. 

In addition to the membrane-inserted core domain of Kv channels, their cytoplasmic domains have important roles for Kv-channel function [5]. Many of these functions are related to subunits assembly, channel trafficking to and from the plasma membrane, and interactions with cytoskeletal components (Fig. la). A tetramerization (T) domain for subunit assembly has been well defined in Shaker-channels, where it is localized in the amino-terminus. Other Kv-channels (e.g., eag, HERG, KvLQTl) may have comparable domains within the cytoplasmic carboxy-terminus. ER retention and retrieval signals have been found... 

Chen, J., Seebohm, G. and Sanguinetti, M.C. (2002) Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of hERG and eag potassium channels. Proceedings of the National Academy of Sciences of the United States of America, 99, 12461-12466. 

Warmke, J.W. and Ganetzky, B. (1994) A family of potassium channel genes related to eag in drosophila and mammals. Proceedings of the National-... 

Ion channels Cng eag Cyclic-nucleotide-gated ion channel protein ether a go-go... 

The eag potassium channel can be modulated by cyclic nucleotides and may play a role in ORNs. Patch-clamp recordings from antennal ORNs in eag mutants show fewer neurons responding to ethyl butyrate (Dubin et al., 1998). Application of high K+ saline to the dendritic side of ORNs raises excitability of most wild type neurons but not in eag mutants, suggesting a role for eag in transduction in ORN dendrites rather than during development (Dubin et al., 1998). 

Meyer R, Heinemann SH (1998) Characterization of an eag-like potassium channel in human neuroblastoma cells. J Physiol 508 49-56... 

Pardo LA, Briiggemann A, Camacho J, Stiihmer W (1998) Cell cycle-related changes in the conducting properties of r-eag K+ channels. J Cell Biol 143 767-775... 

Pardo LA, del Camino D, Sanchez A, Alves F, Bruggemann A, Beckh S, Stuhmer W (1999) Oncogenic potential of EAG K+ channels. EMBO J 18 5540-5547... 

Warmke J, Drysdale R, Ganetzky B (1991) A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science 252 1560-1562... 

Figure 7.9 Experimentally determined heats of adsorption of n-hexane plotted against eage size of channel diameter for a series of pure silica zeolite polymorphs and aluminophosphates.

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