Dysentery, treatment

Opium is the dried, powdered sap of the unripe seed pod of Papaver somniferum, a poppy plant indigenous to Asia minor. Theophrastus described its medical properties in the third century BC, but the Sumerians, ca BC 4000, probably perceived its utility. Arab physicians knew of the dmg, and Arab traders carried it to the Orient where it was used as a treatment for dysentery. Paracelsus is credited with repopularizing the dmg in western Europe in the early sixteenth century by formulating opium into "laudanum", which is still in use. More than 20 different alkaloids (qv) of two different classes comprise 25% of the weight of dry opium. The benzylisoquinolines, characterized by papaverine [58-74-2] (1.0%), a smooth muscle relaxant, and noscapine [128-62-1] (6.0%), an antitussive agent, do not have any analgesic effects. The phenanthrenes, the second group, are the more common and include 10% morphine (1, = R = H), 0.5% codeine [76-57-3], C gH2 N03, (1, R = H, R = CH3), and 0.2 thebaine [115-37-7], C 2H2 N03, (2). 

Nifuraldezone. Aminooxoacetic acid [(5-nitro-2-furanyl)methylene]-hydrazide, nifiiraldezone, is prepared by the reaction of 5-nitro-2-furancarboxaldehyde with semioxamazide. The product is useful in the treatment of dysentery in calves (39). 

Paromomycin. Paromomycin [7542-37-2] is a broad-spectmm antibiotic that has been used in the treatment of fi nana and T. saginata and amebiasis, and also as an antibacterial agent in cases of diarrhea and dysentery (see Antibiotics, oligosaccharides). 

Bismuth compounds were once employed for the treatment of amoebic dysentery, certain skin diseases, and several spirochetal diseases besides syphilis, but these substances are now seldom considered the dmgs of choice. Various insoluble preparations of bismuth, especially the subcarbonate, subnitrate, subgaHate, subcitrate, and subsahcylate, are stiU employed for the treatment of ulcers and other gastrointestinal disorders, even though use for these purposes is often supported largely by tradition. With a few possible exceptions, it is now difficult to justify the presence of bismuth compounds in a modem therapeutic armamentarium. A review of the biological activity of organobismuth compounds has been pubHshed (179). 

Certain halogen derivatives of 8-hydroxyquinoline have a record of therapeutic efficacy in the treatment of cutaneous fungus infections and also of amebic dysentery. Among these are 5-chloro-7-iodo-8-quinolinol [130-26-7] (iodochlorhydroxyquin, Vioform), 5,7-diiodo-8-hydroxyquinoline [83-73-8] (diiodohydroxyquin), and sodium 7-iodo-8-hydroxyquinoline-5-sulfonate [885-04-1] (chiniofon) (196—198). 

Pathogenic organisms Bacteria, viruses or cysts which cause disease (typhoid, cholera, dysentery) in a host (such as a person). There are many types of bacteria (non-pathogenic) which do NOT cause disease. Many beneficial bacteria are found in wastewater treatment processes actively cleaning up organic wastes. 

Paromomycin finds special use in the treatment of intestinal amoebiasis (it is amoebicidal against histolytica) and of acute bacillary dysentery. 

LONGANGA OTSHUDI A, VERCRUYSSE A, FORIERS A (2000) Contribution to the ethnohotanical, phytochemical and pharmacological studies of traditionally used medicinal plants in the treatment of dysentery and diarrhoea in Lomela area. Democratic Repuhhc of Congo (DKC). J Ethnopharmacol. 71 411-23. 

OTSHUDI A L, FORIERS A, VERCRUYSSE A, VAN ZEEBROECK A, LAUWERS S (2000) / vittV antimicrobial activity of six medicinal plants traditionally used for the treatment of dysentery and diarrhoea in Democratic Repnblic of Congo (DRC). Phytomedicine. 7 167-72. 

Rifaximin is likely to be effective in the treatment of milder forms of shigellosis and has been shown to be effective at preventing infection owing to S. flexneri.10 Antimotility agents are not recommended because they can worsen dysentery and may be related to the development of toxic megacolon. No vaccines are licensed currently for the prevention of shigellosis. 

Arsenic compounds have been used in medicine since the time of Hippocrates, ca. 400 BCE (Woolson 1975). Inorganic arsenicals have been used for centuries, and organoarsenicals for at least a century in the treatment of syphilis, yaws, amoebic dysentery, and trypanosomiasis (NAS... 

Shigellosis is usually a self-limiting disease. Most patients recover in 4 to 7 days. Treatment of bacillary dysentery generally includes correction of fluid and electrolyte disturbances and, occasionally, antimicrobials. 

Troupin has also been reported . These alkaloids were found to exhibit antimicrobial and antiplasmodial activities. Epinetrum villosum is a twining liana, growing in secondary forests in the coastal areas in Congo and Angola and is used in traditional medical for the treatment of fever, malaria and dysentery . The genus Cissampelos contains cissampareine, which has potential medicinal uses, but it is also psychoactive. It is a principal alkaloid of dawidjiewortel (Cissampelos capensis), which grows in South Africa. 

Schumanniophyton magnificum has been the source of most of the alkaloids so far isolated. It has several interesting uses in traditional medicine. In Cameroon the bark is used for dysentery as an enema (70). The phenolic compounds present may exert an astringent effect to account for this. In Nigeria the stem juice is used as a treatment for snakebite and the roots are used to treat madness. 

Nepal. Decoction of the leaf is taken orally by adults as an anthelmintic" """. The powdered leaf is mixed with cattle feed as a treatment for diarrhea " " . For headache, the dried leaves are ground with Datura stramonium leaves and Picrorhiza schrophu lariflora stem and water then applied externally" " ". The leaf juice is used externally as an antiseptic, as a hemostat on cuts and wounds, and to treat swelling of sprained joints" "". The seeds are crushed, mixed with curd, and taken orally for dysentery" """. Decoction of the seed is taken orally as an anthelmintic" ". To aid in parturition, 2 teaspoonfuls of powdered seeds... 

Diloxanide furoate is the furoate ester of 2,3-dichloro-4-hydroxy-A-methyl acetanilide. This antiamoebic drug was developed as a result of the discovery that various a,a-dichloroacetamides possessed an amoebicidal activity [1]. Diloxanide furoate is considered as a safe and effective drug for the treatment of asymptotic or mildly symptomatic persons who are passing cysts of Entameba histolytica [2,3], It acts principally in the bowel lumen, and is used in the treatment of the intestinal amoebiasis. It is less effective in amebic dysentery than in asymptotic infection, but the furoate gives high intestinal concentrations and is possibly more effective than metronidazole in the treatment of cyst passers [4],... 

This is mainly employed for the treatment of gastrointestinal infections e.g. bacillary dysentery, giardiasis, bacterial enteritis etc. 

Lmie MN (1938) Treatment of dysentery and haemolytic intestinal diseases among children and adults. Selected Papers of Azerbaijani Institute of Epidemiology and Microbiology 6 31-34... 

Vlasov KF, Artemenko EA (1946) Treatment of chronic dysentery. Sovetskaia Meditsina (Russian Soviet Medicine ) 10 22-28... 

Metronidazole plus a luminal amebicide is the treatment of choice for amebic colitis and dysentery. Tetracyclines and erythromycin are alternative drugs for moderate colitis but are not effective against extraintestinal disease. Dehydroemetine or emetine can also be used, but are best avoided because of toxicity. 

These three herbs are bitter and cold, and their moving tendency in the body is downward. They enter the Liver and Large Intestine meridians. They are effective for clearing heat in the Lower-Jiao, cooling blood and stopping bleeding, and are used in the treatment of colitis, dysentery and hemorrhoids. 

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