Amoebicidal activity

Leon-Sicairos, N., Lopez-Soto, F., Reyes-Lopez, M., Godinez-Vargas, D., Ordaz-Pichardo, C., and de la, G. M. (2006). Amoebicidal activity of milk, apo-lactoferrin, sIgA and lysozyme. Clin. Med. Res. 4,106-113. 

Diloxanide furoate is the furoate ester of 2,3-dichloro-4-hydroxy-A-methyl acetanilide. This antiamoebic drug was developed as a result of the discovery that various a,a-dichloroacetamides possessed an amoebicidal activity [1]. Diloxanide furoate is considered as a safe and effective drug for the treatment of asymptotic or mildly symptomatic persons who are passing cysts of Entameba histolytica [2,3], It acts principally in the bowel lumen, and is used in the treatment of the intestinal amoebiasis. It is less effective in amebic dysentery than in asymptotic infection, but the furoate gives high intestinal concentrations and is possibly more effective than metronidazole in the treatment of cyst passers [4],... 

PHMB and chlorhexidine were found to be the most successful cysticidal agents. Neomycin was reported to be ineffective against neomycin, propamidine Acanthamoeba cysts in vivo. The cysticidal effectiveness of propamidine was more variable than its trophozoite amoebicidal activity... 

Hexamidine, propamidine Hexamidine demonstrated greater amoebicidal activity than propamidine. Perrine et al. recommended replacing propamidine with... 

In practice, treatment of amoebiasis can be divided into treatment of bowel lumen amoebiasis, and tissue-invading amoebiasis. The bowel lumen infection, which is usually asymptomatic, may be in trophozoites form (non-infective) or in cysts form (infective) and treatment is directed at eradicating cysts with a luminal amoebicide (e.g. diloxanide). The tissue-invading amoebiasis (giving rise to dysentery, hepatic amoebiasis and liver abscess) must be treated with systemically active drugs (systemic amoebicides) active against trophozoites (e.g. metronidazole, tinidazole also, in dangerously ill patients dehydroemetine may be used, which is less toxic than the parent emetine (derived from ipecacuanha). Sometimes antibiotics (e.g. tetracycline) are used concurrently to stop opportunist infections. 

Dindevan phenindione. dinitoimide [ban, inn] is a dinitrobenzamide derivative with AMOEBICIDAL activity. It can be used as an ANTICOCCIDIAL poultry feed additive. 

Both chlorbetamide (3) and chloramphenicol (4) possess in intro activity against . histolytica. This fact when taken in conjunction with the high order of amoebicidal activity of chlorbetamide in experimental animals and humans [9-11]... 

Homolatifolin (492) has been prepared from the 18-cyanopregnenolene derivative (491) by the route shown in Scheme 9. Further conversion led to the preparation of 18-homoconessine, possessing decreased amoebicidal activity. 

Many activities in quassinoid area were due partly to the fact these natural products possess a wide spectrum of biological properties including in vivo antileukemic, antiviral, antimalarial, antifeedant, and amoebicidal activity. 

J.D. Phillipson, In K. Hostettman (Ed), Methods in Plant Biochemistry Volume 6, Assays for Antimalarial and Amoebicidal Activities, Academic Press Ltd., London, (1991), p. 135. 

Amoebiasis - Inhibition of Entamoeba histolytica protein synthesis was correlated with the amoebicidal activity of a number of alkaloids and antibiotics. 

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