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Drug processing

P. B. E)e3.sy, Microencapsu/ation and Related Drug Processes, Marcel Dekker, Inc., New York, 1984. [Pg.326]

Ernest J. Henley and Nathaniel E Barr, Ionizing Radiation Applied to Chemical Processes and to Food and Drug Processing... [Pg.342]

Guide to Inspection of Computerized Systems in Drug Processing, found at http //www.fda.gov/ora/inspect ref/igs/csd.html. [Pg.294]

If everything except the concentration of drug in the body is constant, the elimination of the drug will be a pseudo-first-order process. This may seem to be a drastic oversimplification, but most in vivo drug processes, in fact, behave as pseudo-first-order processes. [Pg.78]

Microencapsulation and Related Drug Processes, Patrick B. Deasy Drugs and Nutrients The Interactive Effects, edited by Daphne A. Roe and T. Colin Campbell... [Pg.5]

A particular toxicity associated with the administration of interferon to humans and experimental animals has been depression of the cytochrome P-450 monooxygenase (MFO) metabolizing enzymes. As a consequence of MFO inhibition following treatment with IFN, the sleep-time of mice treated with hexabarbital is increased, as is the toxicity of acetaminophen (Stebbing and Week, 1984). Possible effects on the metabolism of chemotherapeutic agents or other drugs processed by the P-450 MFOs should be anticipated. [Pg.416]

Chemburkar, S. R., et. al., 2000, Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development, Organic Process R D, 4, 413-417. [Pg.81]

Microencapsulation and Related Drug Processes, Patrick B. Deasy... [Pg.4]

Z0124 Yoshikawa, M., N. Chatani, S. Hatakeyama, Y. Nishino, J. Yamahara, and N. Murakami. Crude drug processing by far-infrared treatment. 11. Chemical fluctuation of the constituents during the drying of Zingiber rhizoma. Yakugaku Zasshi 1993 113(10) 712-717. [Pg.549]

Figure 1.2 The three phases of drug processing. The journey from the point of administration to the microenvironment of the receptor is a complex and arduous journey for the drug molecule. (Adapted from D. G. Grahame-Smith, J. K. Aronson (2002). Clinical Pharmacology and Drug Therapy, 3rd Edn. New York Oxford University Press. With permission.)... Figure 1.2 The three phases of drug processing. The journey from the point of administration to the microenvironment of the receptor is a complex and arduous journey for the drug molecule. (Adapted from D. G. Grahame-Smith, J. K. Aronson (2002). Clinical Pharmacology and Drug Therapy, 3rd Edn. New York Oxford University Press. With permission.)...
Figure 1.3 The three phases of drug processing. Different organ systems inflict varying degrees of assault on the integrity of the drug molecule during its journey to the receptor. Stomach acid initiates the assault. Liver enzymes may destroy the drug in a first pass effect. If the drug is too polar, the kidney will rapidly excrete it. Figure 1.3 The three phases of drug processing. Different organ systems inflict varying degrees of assault on the integrity of the drug molecule during its journey to the receptor. Stomach acid initiates the assault. Liver enzymes may destroy the drug in a first pass effect. If the drug is too polar, the kidney will rapidly excrete it.
The circulatory system of fish is also unique structurally and functionally. Structurally, the membranous nature of the vasculature makes for a friable high-capacitance system under low pressure. Low blood flows result in somewhat longer distributional phases for many drugs. Processes such as heart rate and stroke volume that influence drug distribution are themselves influenced by external factors such as temperature and stress. In addition, total plasma protein content differs in fish as compared to mammals. Total plasma protein in the trout and flounder is approximately one-half that of mammals such as dogs and cats. For many compounds protein binding is considerably lower in fish than their mammalian counterparts (19, 20). [Pg.23]

Pro drugs - [PROCESS ENERGY CONSERVATION] (Vol 20) -role m drug delivery systems pRUG DELIVERY SYSTEMS] (Vol 8)... [Pg.813]

Kitagawa I, Fukuda Y, Taniyama T, Yoshikawa M (1995) Chemical Studies on Crude Drug Processing. VEI. On the Constituents of Rehmanniae Radix. (2) Absolute Stereostructures of Rehmaglutin C and Glutinoside Isolated from Chinese Rehmanniae Radix, the Dried Root of Rehmannia glutinosa Libosch. Chem Pharm Bull 43 1096... [Pg.415]

The term process validation is not defined in the Food, Drug, and Cosmetic Act (FD C) Act or in FDA s CGMP regulations. Many definitions have been offered that in general express the same idea—that a process will do what it purports to do, or that the process works and the proof is documented. A June 1978 FDA compliance program on drug process inspections [2] contained the following definition ... [Pg.41]

Deasy, P. Polymerization procedures for biodegradable micro- and nanocapsules and particles, in Microencapsulation and Related Drug Processes. Drugs and the Pharmaceutical Sciences, ed. J. Swarbrick, Vol. 20. New York Marcel Dekker, 1984, pp. 219-240. [Pg.299]

The proliferation of computers in the production of pharmaceuticals resulted in the U.S. Food and Drug Administration (FDA) publishing the "Guide to Inspection of Computerized Systems in Drug Processing" in 1983. FDA Inspectors have been using this guideline for the past three years to cite firms for their failure to validate their computer systems. [Pg.66]

Motise, Paul J. Pharmaceutical Technology March, 1984, "Validation of Computerized Systems in the Control of Drug Processes An FDA Perspective". [Pg.74]

FDA, CPG 7132a. 11, Computerized Drug Processing, CGMP Applicability to Hard-ware and Software, 9/4/87. [Pg.17]


See other pages where Drug processing is mentioned: [Pg.287]    [Pg.310]    [Pg.318]    [Pg.534]    [Pg.396]    [Pg.48]    [Pg.117]    [Pg.302]    [Pg.453]    [Pg.527]    [Pg.46]    [Pg.291]    [Pg.636]   
See also in sourсe #XX -- [ Pg.58 , Pg.59 , Pg.64 , Pg.66 ]




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Absorption, drug gastrointestinal processes affecting

An Overview of the Drug Discovery and Development Process

Applications of Multicomponent Reactions in Drug Discovery - Lead Generation to Process Development

Bioavailability drug discovery process

Biotransformation processes Drug metabolism)

Bulk Drugs Process Design, Technology Transfer, and First Manufacture

Clinical trials drug approval process

Clinical trials drug development process

Closing—The Processing Technologies of Bulk Drugs

Consequences of Excited State Processes to Drug Stability in Vitro

Crystals drug substance, process chemistry

Development process of drugs

Drug Master File process

Drug absorption process

Drug approval process

Drug approval process animal testing

Drug approval process animal trials

Drug approval process removal from market

Drug approvals, process phases

Drug assessment process

Drug design process

Drug development process

Drug development process clinical phase

Drug development process lead optimisation

Drug development process patents

Drug development process stability role

Drug development process toxicological phase

Drug development process, productivity

Drug development randomization process

Drug discoveiy process

Drug discovery process

Drug discovery process overview

Drug discovery synthetic process used

Drug elimination process

Drug formulation development process parameters

Drug package process

Drug processing, computer systems

Drug processing, computer systems validation

Drug regulatory process

Drug research process

Drug screening process

Drugs development/testing process

Drugs, generic approvals, process

Drugs, pharmaceutical approvals, process

Enzyme drug discovery process

Extraction process, small molecule potential drugs

FDA drug approval process

Free drugs, distribution processes

Gastrointestinal tract processes affecting drug absorption

How Drugs Work Altering Mental Processes

Image processing, drug delivery

Incorporation of NMR into the Drug Discovery Process

Introduction to natural product drug discovery process

Investigational New Drugs Application Process

Investigational New Drugs Application Process Phase

Is in Vivo Drug Dissolution a Fractal Process

Japan drug regulatory process

Manufacturing Process Development for Low-Dose Drug Products

Manufacturing Process of the Drug Substance

Manufacturing Process or Equipment for the Drug Product

Manufacturing processes, drug absorption

Needs of the Drug Discovery Process

New Concepts in the Drug Discovery Process

New drug application process

New drug application review process

New drug approval process

New drug development process

Oral drug absorption process

Oral drug absorption rate-limiting processes

Orphan drugs regulatory processes

Pharmaceutical industry drug discovery process

Pharmaceutical research drug development process

Poly gels drug delivery process

Process chemistry drug development events

Process design, enantiopure drugs

Processing Responsibility in Bulk Drug Process Development

Regulatory authorities drug development process

Sterile drug aseptic processing

Structure based drug design process

Surrogate Markers in Different Stages of Drug Development Processes

Target drug discovery process

Technology Transfer of the Bulk Drug Process and First Manufacture

Terminology and processes used in drug manufacture

The Drug Discovery Process

The Drug-Discovery Process cannot be

The FDAs Drug Review Process Ensuring Drugs Are Safe and Effective

The Modern Drug Discovery Process

The drug development process

The drug manufacturing process

The process of drug absorption

Tools and Their Integration in the Drug Discovery Process

Transcellular drug transport carrier-mediated processes

Transporter drug discovery process

Variations to the Drug Authorisation Process

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