Drug research process

Jorgensen, H., 6c Harris, J. S. (1992). The drug research process. Dermatology Nursing, 4. 

Figure 9-1 describes the modern drug research process. Our drug discovery program focuses on new lead discovery and lead optimization, using natural products as a reservoir of biologically active compounds. Many efforts have attempted to... 

The partition coefficient and aqueous solubility are properties important for the study of the adsorption, distribution, metabolism, excretion, and toxicity (ADME-Tox) of drugs. The prediction of the ADME-Tox properties of drug candidates has recently attracted much interest because these properties account for the failure of about 60 % of all drug candidates in the clinical phases. The prediction of these properties in an early phase of the drug development process could therefore lead to significant savings in research and development costs. 

Overall, WebLab MedChem Explorer is very easy to use. The stepwise job setup works well, assuming that all users will be following a conventional drug rehnement process. It is not a program that can be used for complex simulations requiring the researcher to manually control many details of the simulation. 

Figure 6 The iterative drug discovery process integrating structural biology, drug design, synthetic chemistry, biological testing, and additional input from other related research areas.

In order to understand how pharmacogenomics can be used in the drug research and development process it is necessary to understand what the aims of each phase of this process are, and are what the questions each phase is trying to answer. 

While most of the technologies described so far have been applied to academic research and the drug discovery processes, some of the applications described in the previous sections can equally well apply to the medical research community. Here the focus will be on some examples of the applications that are more exclusively relevant to this community, and will include aspects relevant to clinical research, both inside and outside the pharmaceutical development process. 

A large drug manufacturer has decided to study this molecule and formulate it into a drug if it proves to be safe and effective. As an aside, the San Bushmen of the Kalahari desert are currently impoverished and oppressed. If P57 becomes a money-making drug in developed countries, it may mean a better life for people of this tribe, since they will receive royalties (money) when the drug is sold. This drug is very early in the research process and it will be several years before it could be available in the United States. 

Identification of metabolic reactions at an early phase can significantly affect the drug discovery process, because bioavailability, activity, toxicity, distribution and final elimination all depend on metabolic biotransformations [1], Once obtained, this information can help researchers judge whether or not a potential candidate should be eliminated from the pipeline or modified to reduce the affinity for CYP antitarget enzymes. 

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