Drug development randomization process

For this reason many are distressed by recent changes which have influenced and will continue to influence both basic biological research and drug development. Some of these changes may be described as changes in national policy. Many, quite obviously, are the inevitable and usually random by-products of the life processes of bureaucratic and political entities and the interactions between them. The most important, however, are changes in the attitudes of government and of society. 

Random screening, a stochastic approach for lead structure retrieval in the drug development process. In high-throughput screening thousands of compounds can be... 

Are graphics used effectively in pharmaceutical research In 2007, Pocock et al. reviewed 77 reports of randomized controlled trials in five medical journals and concluded that there is "considerable scope for authors to improve their use of figures in clinical trial reports." It is the premise of an entire book, A Picture Is Worth a Thousand Tables Graphics in Life Sciences, that "drug development processes are still largely reliant on tables and listings." ... 

Djulbegovic, B., Hozo, L, loannidis, J.P.A. Improving the drug development process more not less randomized trials. JAMA 311, 355-356 (2014). doi 10.1001/ jama.2013.283742... 

Combinatorial chemistry, a new chapter of organic synthesis, is now developing rapidly. This new approach to synthesizing large designed or random chemical libraries through application of solid phase synthetic methods, promises to revolutionize the process of drug discovery in the pharmaceutical industry.24... 

Once a SAR is developed, it can be used to prioritize further research efforts by focusing first on molecules predicted by the SAR to have the most desirable activity. Thus, if a drug company has a database of several hundred thousand molecules that it has synthesized over the years, and it has measured molecular properties for those compounds, once it identifies a SAR for some particular bio-target, it can quickly run its database through the SAR to identify other molecules tliat should be examined. However, this process is not very useful for identifying new molecules that might be better than any presently existing ones. It can be quite expensive to synthesize new molecules randomly, so how can that process be similarly prioritized ... 

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