Gastrointestinal tract processes affecting drug absorption

Figure 8.10 Gastrointestinal tract with processes affecting drug absorption efficiency.

Figure 2.1 Oral drag absorption process from the gastrointestinal tract (GIT). Schematic depicting the three major processes (/a, / and /h) affecting absorption of drug from the site of administration to the systemic circulation, that is oral bioavailability, /a- fg, and /h can be estimated from the general relationship provided in Eq. 2.3 ...

The gastrointestinal tract is the main site of action of acarbose, which is metabolized exclusively within the gastrointestinal tract, principally by intestinal bacteria this process may be adversely affected by antibiotics that alter the intestinal bacterial flora. Acarbose affects the absorption of some drugs (e.g. digoxin). 

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