Closing—The Processing Technologies of Bulk Drugs

It is not in the scope of this chapter to address this topic in any breadth and least of all in any depth. The variety of the technologies is too large and the field far too rich. Instead, some selected observations that the new practitioner might find useful follow. 

Process development organizations that lack a sufficient engineering component often miss the opportu- 

Product purity and consistency, which are paramount norms in bulk drug manufacturing, are today observed through the impurity profiles to an unprecedented extent. This puts a great deal of pressure on the mastery of purification methods, mostly on those based on crystallization from solution. 

Poliak P. From a commodities business to the world s leading manufacturer of exclusive fine chemicals. Chim Oggi 1997 15 75-81. 

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