Drug, drugs characterization

The tricyclic antidepressants (as well as, incidentally the antipsychotic drugs) are characterized by a three carbon chain between the ring system and the basic nitrogen. Incorporation of one of those carbon atoms into an additional fused ring is apparently consistent with activity. Preparation of this compound involves first homologation of the side chain. Thus the carboxylic acid 147 is first converted... [Pg.246]

Physicochemical properties of the drug Pharmacokinetic characterization of the drug Reliability... [Pg.26]

Tavelin, S., J. Taipalensuu, F. Hallbook, K. Vellonen, V. Moore, and P. Artursson. An Improved Cell Culture Model Based on 2/4/A1 Cell Monolayers for Studies of Intestinal Drug Transport. Characterization of Transport Routes., Pharm. Res. 2003, 20, 373-381. [Pg.89]

Skovsgaard, T., Stein, W. D., Structure—activity relationships of P-glycoprotein interacting drugs kinetic characterization of their effects on ATPase activity, Biochim. Biophys. Acta... [Pg.488]

S. H. Fleishman and C. L. Brooks, Protein drug interactions Characterization of... [Pg.280]

For the dissolution test to be used as an effective drug product characterization and quality control tool, the method must be developed with the various end uses in mind. In some cases, the method used in the early phase of product and formulation development could be different from the final test procedure utilized for control of the product quality. Methods used for formulation screening or BA and/or bioequivalency evaluations may simply be impractical for a quality control environment. It is essential that with the accumulation of experience, the early method be critically re-evaluated and potentially simplified, giving preference to compendial apparatus and media. Hence, the final dissolution method submitted for product registration may not necessarily closely imitate the in vivo environment but should still test the key performance indicators of the formulation. [Pg.353]

Tavelin S, Taipalensuu J, Hallbook F, Vellonen KS, Moore V, Artursson P (2003a) An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport Characterization of transport routes. Pharm Res 20 373-381. [Pg.213]

All other steps, which include loading of these liposomes with DOX-HCl, removal of residual free drug, and characterization of the SSL during the various steps of preparation as well as of the final product, are described below and summarized in Table 2. [Pg.15]

The effects of these drugs are practically identical. This group of drugs is characterized by three main side effects (1) hyperuricemia, (2) hyperglycemia, and (3) irregular elecffolytic balance that can be characterized by hypercalcemia, hypochloremia, and metabolic alkalosis. [Pg.298]

Jurva, U., Holmen, A., Grdnberg, G., Masimirembwa, C. and Weidolf, L. (2008) Electrochemical generation of electrophilic drug metabolites characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR. Chemical Research in Toxicology, 21 (4), 928-935. [Pg.163]

Antipsychotic drugs are characterized by high therapeutic indices with respect to mortality, but side effects occur routinely at therapeutic doses, mostly as exten-... [Pg.401]

PET and SPECT are increasingly used in drug development. Characterization of longitudinal changes in glucose metabolism in AD and other dementias has... [Pg.71]

Therapeutic response to the drug, as characterized by increased ability to concentrate, improvement in self-care, interest in surroundings, and a relaxed facial expression... [Pg.706]

POLYPEPTIDE AND PROTEIN DRUGS Production, Characterization and Formulation... [Pg.2]

Kumi KI, Booth BP. A regulatory view of liposomal drug product characterization. New Drug Development. Marcel Dekker, Inc., 2004. [Pg.14]

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