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Drug discovery physicochemical characterization

It is important to characterize the physicochemical properties of the suspensions well, so that the PK data can be interpreted appropriately. Typical characterization of the drug substance includes purity, residual solvents, aqueous solubility pro Lie (pH 2, FaSSIF), crystallinity (XRPD/DSC), particle size, pl and logP. For solution formulations at various stages of discovery studies, dose analysis is essential, and for efLcacy assessment and toxicology studies, chemical stability for the... [Pg.127]

Many types of modeling techniques are available in the discovery phase of drug development, from structure activity relationships (SAR) to physiology based pharmacokinetics (PBPK) and pharmacokinetics-/pharmacodynamics (PK/PD) to help choosing some of the lead compounds. Some tests that are carried out by discovery include techniques related to structure determination, metabolism, and permeability NMR, MS/MS, elemental analysis, PAMPA, CACO-2, and in vitro metabolic stability. Although they are important as a part of physicochemical molecular characterization under the biopharmaceutics umbrella, they will not be discussed here. The reader can find relevant information in numerous monographs [9,10]. [Pg.580]

See other pages where Drug discovery physicochemical characterization is mentioned: [Pg.178]    [Pg.209]    [Pg.67]    [Pg.57]    [Pg.81]    [Pg.285]    [Pg.452]    [Pg.454]    [Pg.599]    [Pg.12]    [Pg.4]    [Pg.330]    [Pg.161]    [Pg.1153]    [Pg.143]    [Pg.369]    [Pg.185]    [Pg.125]    [Pg.415]    [Pg.22]    [Pg.859]    [Pg.651]    [Pg.859]    [Pg.389]    [Pg.144]   
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