Drug discovery characterization

Bray KL (2001) High Pressure Probes of Electronic Structure and Luminescence Properties of Transition Metal and Lanthanide Systems. 213 1-94 Bronstein LM (2003) Nanoparticles Made in Mesoporous Solids. 226 55-89 Bronstrup M (2003) High Throughput Mass Spectrometry for Compound Characterization in Drug Discovery. 225 275-294... 

Ghose, A. K., Viswanadhan, V. N., Wendoloski, J. J. A knowledge-based approach in designing combinatorial or medicinal chemistty libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases./. Comb. Chem. 1999, 1, 55-58. 

In the realm of drug discovery, the detection and characterization of target-ligand interactions is a critical process for lead identification, validation, and optimization. 

Isolation and characterization of new indole alkaloids remains a fruitful avenue for the discovery of agents with the potential for biomedical application. The virtues of this age-old process, in light of advances in combinatorial chemistry, were brought to the community as part of the 231 ACS National Meeting symposium, Modern Natural Products Chemistry and Drug Discovery <06ORGN467>. 

Online LC-MS is a good solution for separation, identification, and quantification because it permits the confirmation of polar and nonvolatile compounds without need for derivatization.4 The use of LC-MS for biological sample detection and data analysis has grown rapidly during the past few years. Many reliable and easy to use LC-MS systems are commercially available and have been adapted for solving analytical problems by scientists in proteomics research, metabolic study, complex natural product separation and characterization, and drug discovery. 

Meyer B. STD NMR to screen libraries and characterize binding, in NMR drug discovery and design - Post-genomic analysis. 2000. McLean, Virginia Cambridge Healthtech Institute. 

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