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Application of Biotechnologies in Drug Discovery and Development

In this section we will focus primarily on recombinant proteins. We will discuss strategies specific to monoclonal antibody production in the introduction to antibodies and derivatives (Chapter 10). Issues specific to peptides will be discussed in the [Pg.35]

Biotechnology and Biopharmaceuticals, by Rodney J. Y. Ho and Milo Gibaldi ISBN 0-471-20690-3 Copyright 2003 by John Wiley Sons, Inc. [Pg.35]

What remains relatively unchanged, however, is how one uses the information available in the literature or other sources to identify the drug candidate that will have an optimal effect on the therapeutic target. The strategy to clone and express disease-related genes also remains unchanged. [Pg.36]

Basic understanding of DNA replication paves the way to isolate and manipulate genes of interest. [Pg.36]

Elucidation of molecular processes involved in transcription and translation [6,7] leads to the development of a bacterial and mammalian protein expression system to mass-produce proteins. [Pg.36]


Biotechnology and Biological Preparations, p. 258. Genetic Aspects of Drug Development, p. 1897. Proteomics Pharmaceutical Applications, p. 3041. Receptors for Drugs Discovery in the Post-Genomic Era, p. 3108. [Pg.2798]

Liquid chromatography is an essential analytical tool for the separation of proteins in biotechnology and pharmaceutical product development. Applications are found throughout the development process of biological products, from drug discovery to quality control. Molecular properties of proteins, like molecular mass, net charge, hydrophobicity, and structure give ample opportunities to use HPLC for their separation. [Pg.598]


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And drug discovery

Applications and Developments

Applications development

Applications in Drug Discovery

Biotechnology and Drug Discovery

Biotechnology development

Biotechnology drugs

Biotechnology, and

Biotechnology, applications

Biotechnology, drug discovery

Developer application

Developing applications

Development of drugs

Discovery and Development of Drugs

Discovery and development

Discovery of drugs

Drug development discovery

Drug discovery and development

Drug discovery applications

In drug discovery

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