Applications in Drug Discovery

Ekins S, Bugrim A, Nikolsky Y, Nikolskaya T. Systems biology applications in drug discovery. In Gad S, editor. Drug discovery handbook. New York Wiley, 2005. p. 123-183. 

Our clients in R D groups for stimulating discussions on R D improvement and for requesting and trialing our recent approaches to the simulations of impact and economic assessment of new ways of working and new technology applications in drug discovery. 

Goodford, P. J. The basic principles of GRID. In Molecular Interaction Fields Application in Drug Discovery and ADME Prediction (Methods and Principles in Medicinal Chemistry), Cruciani, G., Mannhold, R. Kubinyi, H., Folkers, G. 

Goodford P (2006) In Cruciani G, Mannhold R, Kubinyi H, Folkers G (eds) Molecular interaction fields applications in drug discovery and ADME prediction. Wiley, New York, p 3... 

The Polar Surface Area and Its Application in Drug Discovery... 

Quantitation and qualification of large molecules follow similar principles as procedures for small molecules but involve different foci and approaches. The quantitation of proteins and peptides includes relative and absolute amount evaluations. Most proteomic applications in drug discovery are concerned with relative abundances of proteins. 

Fernandes T.G. Diogo M.M. Clark D.S. Dordick J.S. Cabral J. High-throughput cellular microarray platforms Applications in drug discovery, toxicology and stem cell research. Trends in Biotechnology, 2009, 27, 342-349. 

Horvath, D. In Combinatorial Library Design and Evaluation. Principles, Software Tools, and Applications in Drug Discovery, Ghose, A.K. and ViSWANADHAN, V.N. (Eds). Marcel Dekker, New York, 2001, 429-472. 

Ghose, A. K. and Viswanadhan, V. N. (eds.) (2001) Combinatorial library design and evaluation principles, software tools and applications in drug discovery. Marcel Dekker, New York. 

Storer, R. Solution-Phase Synthesis in Combinatorial Chemistry Applications in Drug Discovery, Drug Discovery Today 1996,1, 248. 

Peng SX. Hyphenated HPLC-NMR and its applications in drug discovery. Biomed Chromatogr 2000 14 430-441. 

Storer, R. 1996. Solution-phase synthesis in combinatorial chemistry applications in drug discovery. Drug Discovery Today, 1,248-254. 

Miller JM, Blackburn AC, Shi Y et al. (2002) Semi-empirical relationships between effective mobility, charge, and molecular weight of pharmaceuticals by pressure-assisted capillary electrophoresis Applications in drug discovery. Electrophoresis 23 2833-2841... 

In addition to isocyanide-based MCRs, a wealth of highly functionalized heterocycles can be obtained from 1,3-dicarbonyl, cyanomalonate and malononitrile based MCRs [19]. These easily accessible starting materials participate in a variety of multi-component reactions and have found numerous applications in drug discovery. 

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