Application to Drug Discovery

Wishart, D. 2005. NMR spectroscopy and protein structure determination applications to drug discovery and development. Current Pharmaceutical Biotechnology 6(2), 105-120. 

Becker, O.M., Shacham, S., Marantz, Y. and Noiman, S. (2003) Modeling the 3D structure of GPCRs advances and application to drug discovery. Current Opinion in Drug Discovery and Development, 6, 3353-3361. 

Mei H, Hseih Y, Nardo C, Xu X, Wang S, et al. 2003. Investigation of matrix effects in bioanalytical high performance liquid chromatography/tandem, mass spectrometrometic assay application to drug discovery. Rapid Commun Mass Spectrom 17 97-103. 

Jeffery DA, Bogyo M. Chemical proteomics and its application to drug discovery. Curr Opin Biotechnol 2003 14 87-95. 

Gordon, E. M. Gallop, M. A. Patel, D. V. Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery, Acc. Chem. Res. 

J. Kobylecki, and J. Steel, Combinatorial synthesis—the design of compound libraries and their application to drug discovery, Tetrahedron 5J 8135 (1995), and references cited therein (b) G. Lowe, Combinatorial chemistry, Chem. Soc. Rev. p. 309(1995) (c) E. R. Felder, The challenge of preparing and testing combinatorial compound libraries in the fast lane, at the front end of drug development, Chimia 48 531 (1994) (d) P. C. Andrews, D. M. Leonard, W. C. Cody, and T. 

Rubakhin, S. S., Jurchen, J. C., Monroe, E. B., and Sweedler, J. V. (2005). Imaging mass spectrometry fundamentals and applications to drug discovery. Drug Discov. Today 10 823-837. 

The exploratory power of the reaction was recognized well before the advent of combinatorial chemistry [46]. Ugi also foresaw initial applications to drug discovery, showing that the widely used local anesthetic Xylocain 43 was accessible in one pot (Scheme 11.8). In this particular variant the water generated in situ after Schiff-base formation traps the intermediate nitrilium ion to give the a-amino carboxamide product. 

Also, one would be remiss if one did not at least mention the various analytical and diagnostic NMR techniques that have come into prominent use over the last decade, particularly with respect to their applications to drug discovery. Because of the sensitivity of its chemical shift to local environment, 19F NMR has increasingly been used as a probe in the study of structure and dynamics of small molecules, proteins, and other biological systems.32-36... 

Terrett NK, Gardner M, Gordon DW, Kobylecki RJ, Steele J, Combinatorial synthesis—the design of compound libraries and their application to drug discovery, Tetrahedron, 51 8135-8173, 1995. 

Gordon EM, Galop MA, Patel DV, Strategy and tactics in combinatorial organic synthesis, Application to drug discovery, Accounts. Chem. Res., 29 144-154, 1996. 

The classic Biginelli reaction features the cyclocondensation of an aldehyde, a urea and an active methylene compound to form dihydropyrimidinones (Fig. 4). The reaction has been extensively utilized and reviewed [20] and its applications to drug discovery have also been highlighted [21]. This chapter will focus on some of the most recent developments and applications of Biginelli reactions to the discovery of biologically active molecules. 

The term chemical diversity is used collectively to describe structural (scaffold) or functionality differences within a collection of compounds. There are numerous scientific publications and reviews on methods for understanding chemical diversity and its application to drug discovery. 

H. Mei, Y. Hsieh, C. Nardo, X. Xu, S. Wang, K. Ng, and W. A. Korfmacher, Investigation of matrix effects in bioanalytical high-performance liqnid chromatogra-phy/tandem mass spectrometric assays Application to drug discovery. Rapid Commun. Mass Spectrom. 17 (2003), 97-103. 

Currently a number of issues, such as robustness of biological systems, network structures and dynamics, and applications to drug discovery are actively investigated. This is allowed by significant advances in science and technology to explore how biological component function as a network at sub-cellular, cellular, tissue or organism levels. 

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