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Drug development trends

DiMasi JA, Paquette C. The economics of follow-on drug development trends in entry rates and the timing of development. PharmacoEcon 2004 22 1-14. [Pg.635]

Kaitin K, Cairns C. The new drug approvals of 1999, 2000, and 2001 drug development trends a decade after passage of the prescription Drug User Pee Act of 1992. Drug Information Journal 2003 4 357-71. [Pg.635]

Powis G (1991) Signalling targets for anticancer drug development. Trends Pharmacol Sci 12 188-194... [Pg.86]

Sterner, O. and Szallasi, A. Novel natural vanilloid receptor agonists new therapeutic targets for drug development, Trends Pharmacol. Sci. 1999, 20, 459-465. [Pg.517]

Balganesh TS, Alzari PM, Cole ST (2008) Rising standards for tuberculosis drug development. Trends Pharmacol Sci 29 576-581... [Pg.153]

Ferguson D, Christopher N (1996) Urine bladder function and drug development. Trends Pharmacol Sci 17 161-165... [Pg.135]

Grundemar L, Hakanson R. Neuropeptide Y effector systems perspectives for drug development. Trends Pharmacol Sci 1994 15 153-159. [Pg.396]

Fakunle, E. S. Loring, J. R 2012. Ethnically diverse pluripotent stem cells for drug development. Trends in Molecular Medicine, 18,709-16. [Pg.343]

To extract the conformational properties of the molecule that is being studied, the conformational ensemble that was sampled and optimized must be analyzed. The analysis may focus on global properties, attempting to characterize features such as overall flexibility or to identify common trends in the conformation set. Alternatively, it may be used to identify a smaller subset of characteristic low energy conformations, which may be used to direct future drug development efforts. It should be stressed that the different conformational analysis tools can be applied to any collection of molecular conformations. These... [Pg.83]

In this chapter we report recent advantages in analytical method hyphenation and chemometric approach applied to drug development, especially related to last trends in pharmaceutical field and to advantages in terms of high-throughputs procedure and instrumentations. [Pg.50]

These data were obtained in April 2002 by Mom Janice Reichert at the Tufts University Center for Study of Drug Development in Boston, Massachusetts. For further trends and analyses in this regard, see the Tufts Center s Inc pact Report, Vol. 3, Nov/Dec 2001. [Pg.540]

DiMasi, J.A., Success rates for new drugs entering clinical testing in the United States, Clin. Pharmacol. Therap., 58,1-14,1995 DiMasi, J.A., Trends in drug development costs, times and risks. Drug Inform. /., 29, 375-384,1995. [Pg.545]

Combined with the trend of small niche companies in drug development has come the parallel corporate trend of downsizing and the hesitancy to expand divisions to take on temporary projects. A great number of large companies are contracting for critical aspects of drug discovery and development. Compounds can be manufactured xmder contract. [Pg.556]

Development trends for monoclonal antibody cancer therapeutics, Nature Reviews Drug Discovery 6 340-356... [Pg.114]

Dorman G, Prestwich GD. 2000. Using photolabile ligands in drug discovery and development. Trends Biotechnol 18 64-77. [Pg.453]

Prosser H, Rastan S. Manipulation of the mouse genome a multiple impact resource for drug discovery and development. Trends Biotechnol 2003 21 224-32. [Pg.76]

Sagi-Eisenberg R GTP binding proteins as possible targets for protein kinase C action. Trends Biochem Sci 14 355-357, 1989 Sahakian BJ, Coull JT Nicotine and THA Evidence for improved attention in patients with dementia of the Alzheimer type. Drug Development Research 31 80-88, 1994... [Pg.738]

BIOTECHNOLOGY PRODUCTS OF MACROMOLECULES AND CHEMICAL PRODUCTS CURRENT TRENDS IN DRUG DEVELOPMENT... [Pg.11]

This is the first time a data base.of this size and degree of comprehensiveness has been compiled on the state of new drug development in any country. We are currently obtaining further information on investigational NCEs, which will include the reasons for termination of clinical research by the firms and full data on licensed compounds. These additional data will clarify some of the trends that have been revealed by the present study, and will allow further analyses to be performed of the reasons behind the observed changes. [Pg.142]

Slater and Savelski note similar trends in solvent use and waste reduction for a new oncology drug under development at BMS [1]. They indicate that the best opportunities to make a process greener occur in the early stages of drug develop-... [Pg.58]

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See also in sourсe #XX -- [ Pg.18 ]



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