Vanilloid receptor agonist

Scheme 1 Chemical structures of natural vanilloid receptor agonists a, capsaicin, the irritant principle in hot peppers b, resiniferatoxin (RTX), isolated from the cactuslike plant Euphorbia resinifera c, the triprenyl phenol scutigeral, found in an edible, non-pungent mushroom d, the sesquiterpenoid dialdehyde isovelleral, found in pungent mushrooms.

Sterner, O. and Szallasi, A. Novel natural vanilloid receptor agonists new therapeutic targets for drug development, Trends Pharmacol. Sci. 1999, 20, 459-465. 

Olvanil [inn, usan] (/V-vanillyloleamide) is a capsaicin analogue regarded as a vanilloid receptor AGONIST. It can be... 

VANILLOID RECEPTOR ANTAGONISTS act at sites activated by sensory irritants, e.g. capsaicin see VANILLOID receptor agonists. Capsazepine, a synthetic compound developed out of vallinoids such as capsaicin, is a high-afflnity competitive vanilloid receptors antagonist. It is used as a pharmacological tool. There is some variation in affinity between different sites and species, suggesting receptor subtypes and species variants. Ruthenium Red also acts as an inhibitor at these sites in a non-competitive manner. 

Andersson DA, Adner M, Hogestatt ED, Zygmunt PM (2002) Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists. Mol Pharmacol 62 705-713... 

Finally, 2-AG has been found to induce contractions in the longitudinal smooth muscle from the guinea-pig distal colon in vitro in a tetrodotoxin-sensitive manner. This response was mimicked by anandamide, but not by the cannabinoid receptor agonist WIN 55,212-2 or the vanilloid receptor agonist AM404 and was not inhibited by antagonists of cannabinoid or vanilloid receptors (Kojima et al. 

Fig.3 Chemical structures of two vanilloid receptor agonists olvanil and capsaicin and of the vanilloid...

Al-Hayani, A., Di Marzo, V., and Davies S. (2003) Homo-N-arachidonoyl-dopamine mimics vanilloid receptor agonists in enhancing paired pulse depression of hippocampal population spikes, Int. Cannabinoid Res. Soc. Symposium, p. 83. 

Geraghty, D.R and Mazzone, S.B. (2002) Respiratory actions of vanilloid receptor agonists in the nucleus of the solitary tract comparison of resiniferatoxin with non-pungent agents and anandamide, Br. J. Pharmacol, 137 919-27. 

KoUarik M, Undem BJ (2003) Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wUd-type and TRPVlt/t mice. J Physiol 555(Part 1) 115-23... 

H. Yamamoto, S. Horie, M. Uchida, S. Tsuchiya, T. Murayama, K. Watanabe (2001) Effects of vanilloid receptor agonists and antagonists on gastric antral ulcers in rats. Eur. J. Pharmacol., 432, 203-210. 

Meyer, D. Mixture of a vanilloid receptor agonist and a substance inhibiting nerve regeneration, use thereof for producing painkiller, and method for applying the painkiller. PCX InL Appl. WO 2006066419, 2006 Chem. Abstr. 2006,145,96461. 

Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya T (2001) Capsaicinlike anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med 67(7) 628-633. doi 10.1055/s-2001-17353... 

Vanilloid receptor agonists Vanilloid receptor antagonists Cannabinoid moduiators Growth factor moduiators... 

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