Biodegradable Polyrotaxanes for Drug Delivery Systems

Synthesis of Biodegradable Polyrotaxanes and Drug-Polyrotaxane Conjugates 

We have synthesized a series of biodegradable polyrotaxanes in which many a-CDs are threaded onto a PEG chain capped with an L-phenylalanine (L-Phe) moiety via a peptide linkage. The S5mthesis was carried out by i) preparing a polypseudorotaxane consisting of a-CD and amino-terminated PEG as previously reported by Harada et and ii) capping both 

3 Drug Release from Biodegradable Polyrotaxanes via Supramolecular Dissociation and its Relation to Solution Properties 

2 In vitro degradation of the drug-polyrotaxane conjugates and theophylline-immobilized HP-a-CD release in relation to their solution properties 

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