Drug delivery system poly nanoparticle

This is a method to obtain colloidal drug delivery systems from preformed, well-defined macromolecular materials with known physicochemical and biological properties. Biodegradable nanoparticles from PLA, PLG, PLGA, and poly(E-caprolactone) have been prepared by dispersing the polymers (Vauthier et al. 1991 Couvreur et al. 1995). 

Pandey, R., Sharma, A., Zahoor, A., Sharma, S., Khuller, G K., and Prasad, B. (2003), Poly (DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis, I. Antimicrob. Chemother., 52, 981-986. 

CHO Choi, C., Chae, S.Y., and Nah, J.-W., Thermosensitive poly(V-isopropylaciylamide)-i-poly(e-caprolactone) nanoparticles for efficient drug delivery system. Polymer, 47, 4571, 2006. 

Wang T, Xu Q, Wu Y, Zeng A, Li M, Gao H. Quaternized chitosan (QCS)/poly (aspartic acid) nanoparticles as a protein drug-delivery system. Carbohydr Res. 2009 344(7) 908-14. 

Montmorillonites / poly(N-isopropyl acrylamide) [16] Norfloxacin Semi-interpenetrated network hydrogels Allows multiresposive drug delivery systems. Norfloxacin release controlled by the presence of montmorillonite nanoparticles and by the viscosity of swollen hybrid hydrogels. Formulations of the hybrid network with Dellite 67 G. nanoparticles showed a better sustained release than that of composites with Dellite HPS and a better balance between the relaxation time and the amount of released drug. 

The most widely investigated temperature-responsive biomedical polymer is poly(A-isopropyl acrylamide) (pNIPAM). This polymer is the focus of Chapter 1 in this book, and therefore it will not be discussed in depth here. However, pNIPAM has been paired with polyampholyte copolymers and applied to nanoparticle separations (Das et al., 2008), drug delivery (Bradley, Liu, Keddie, Vincent, Burnett, 2009 Bradley, Vincent, Burnett, 2009), and tissue engineering applications (Xu et al., 2008). In a related system, latridi et al. (2011) also used the LCST-responsive properties of polyethylene glycol methacrylate (PEGMA) copolymerized with methac-rylic acid and 2-(diethylamino) ethyl methacrylate in a temperature- and pH-sensitive doxorubicin drug delivery system. However, the primary focus of this study was to demonstrate the pH-dependent release properties as discussed earlier. 

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