Polyethylene glycol methacrylate

FIG. 14 Platelet adhesion to the PU films grafted with methoxy polyethylene glycol) methacrylates at different concentrations of chain transfer agent (c-cysteine). Ethylene glycol units in monomers ( ) 4, (O) 9, and ( ) 23. (From Ref. 74.)... 

Graft copolymers were prepared by both classical strategies, that is, from enzymatically obtained macromonomers by subsequent chemical polymerization and by enzymatic grafting from hydroxyl functional polymers. Kalra et al. studied the synthesis of PPDL graft copolymers from macromonomers, which were obtained by the enzymatic ROP of pentadecalactone (PDL) from hydroxyethyl methacrylate (HEMA) and polyethylene glycol) methacrylate (PEGMA) [40]. Subsequently graft copolymers were obtained by free radical polymerization of the macromonomers. A similar approach was published by Srivastava for the HEMA-initiated enzymatic ROP of CL and subsequent free radical polymerization [41]. 

Sun, Y.H., Gombotz, W.R., and Hoffman, A.S. 1986. Synthesis and characterization of non-fouling polymer surfaces I. Radiation grafting of hydroxyethyl methacrylate and polyethylene glycol methacrylate onto silastic film. J Bioact Comp Polym. 1 317-334. 

Immobilization through inclusion into a gel, similarly to immobilization by adsorption, is a physical method of protein fixation. Advantages of such a method are its simplicity and the absence of chemical modification of the enzyme molecules. Polyacrylamide, polyethylene glycol methacrylate, polysaccharide, polyionite, as well as various inorganic gels are used. 

Polyethylene glycol methacrylate gel is formed during copolymerization of methacrylate ethylene glycol and dimethacrylate ethylene glycol. The gels obtained are similar to the polyacrylamide ones but have better mechanical properties and transparency, and are more hydrophobic. 

Sun, Y., Hoffman. A. S., and Gombotz, W. R.. Non-fouling biomaterial surfaces II. Protein adsorption on radiation grafted polyethylene glycol methacrylate copolymers, Polym. Prep., 25(1) 292 (1987). 

The material so frinctionalized constitutes a multiarm macroinitiator for ATRP processes. From this core was grown a polar corona by foe polymerization of polyethylene glycol methacrylate (PGG-DP - 7 ) using bis-tr henyl ho hiiie nickel n bromide as foe catalyst in tolumie (95 C, 40% solids, initiator/catalyst = 0.23, nickel/monomer = 0.019 ). The anqrhiphilic product was isolated by prec itation and foe polymer data listed in Table 1. Hoe GPC aiuilysis is particularly troublesome, since foe materials stick to foe column resulting in very low estimates for the molecular weight From H-NMR, foe degree of polymerization/arm was estimated at 14 and foe measured Rfc (THF) = 10.1 nm ( 20% size increase relative to the polystyrene core). 

The most widely investigated temperature-responsive biomedical polymer is poly(A-isopropyl acrylamide) (pNIPAM). This polymer is the focus of Chapter 1 in this book, and therefore it will not be discussed in depth here. However, pNIPAM has been paired with polyampholyte copolymers and applied to nanoparticle separations (Das et al., 2008), drug delivery (Bradley, Liu, Keddie, Vincent, Burnett, 2009 Bradley, Vincent, Burnett, 2009), and tissue engineering applications (Xu et al., 2008). In a related system, latridi et al. (2011) also used the LCST-responsive properties of polyethylene glycol methacrylate (PEGMA) copolymerized with methac-rylic acid and 2-(diethylamino) ethyl methacrylate in a temperature- and pH-sensitive doxorubicin drug delivery system. However, the primary focus of this study was to demonstrate the pH-dependent release properties as discussed earlier. 

Liao C, Sun X-G, Dai S (2013) CrossUiiked gel polymer electrolytes based on polyethylene glycol methacrylate and ionic liquid for lithium ion battery applications. Electrochim Acta 87 889-894. doi 10.1016/j.electacta.2012.10.027... 

Poly(ethylene glycol), dimethacrylate Polyethylene glycol methacrylate 25852-47-S Poly(oxy-l, 2-ethanediyl). a-(2-methyl-1 -oxo-2-propenyl)-(0-((2-methyl-1-0X0-2-propenyl)oxy)- R (C2H40) CxH 10O3... 

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