Lack significance

The components in catalysts called promoters lack significant catalytic activity tliemselves, but tliey improve a catalyst by making it more active, selective, or stable. A chemical promoter is used in minute amounts (e.g., parts per million) and affects tlie chemistry of tlie catalysis by influencing or being part of tlie catalytic sites. A textural (structural) promoter, on tlie otlier hand, is used in massive amounts and usually plays a role such as stabilization of tlie catalyst, for instance, by reducing tlie tendency of tlie porous material to collapse or sinter and lose internal surface area, which is a mechanism of deactivation. 

Numerous experimental therapeutics have shown potency in vitro however, when they are tested in vivo, they often lack significant efficacy. This is often attributed to unfavorable pharmacokinetic properties and systemic toxicity, which limit the maximum tolerated dose. These limitations can be overcome by use of drug carriers. Two general types of carrier systems have been designed drug conjugation to macromolecular carriers, such as polymers and proteins and drug encapsulation in nanocarriers, such as liposomes, polymersomes and micelles. 

A sample of 823 stars with abundances of several elements (Fe,0,Mg,Ti,Si, Na,Ni,Al) was compiled from several papers (Ref 1 to 10) after checking the lack significant differences between their results. The velocities (U,V,W) and orbital parameters were computed for 640 Hipparcos stars having <0.25, to make a large database combining kinematics and detailed abundances. Ages of 442 stars were retrieved from Nordstrom et al(2004). 

In general, the inhibitory activity of 7-(2/-pyridylmethylidene) cepham sulfones remains high, but the 7-position carboxylate was low. Similarly, 7-(2/-thiazolidinyl) methylidene cephalosporin 171 lacks significant inhibitory activity. 

The three pigments, Pigment Red 89, Pigment Yellow 123, and 193, however, currently lack significant commercial use. 

Although U. reticulata lacks significant larval biofouling, it harbors a variety of epibiotic bacterial species. Dobretsov and Qian (2002) evaluated the antifouling effects of seven bacterial species cultured from U. reticulata surfaces. The extract... 

ULPs are still classified as DUBs because the function and mechanism of catalysis is so similar to those of the DUBs that act on ubiquitin. ULPs lack significant sequence homology to other DUBs and are more closely related to viral proteinprocessing proteases [39]. 

A more recent and much more complete calculation at the MC-SCF-CI level by Blomberg and Wahlgren134 on the dianion of Ni(edt)2 produced the wrong ground state configuration (tetrahedral), and an estimate of d-d excitation energies, while made, lacked significance. 

While the initial studies in gene-targeted mice suggest that PAR in the CNS may play an important role in memory function, further studies are required to better understand the role of central PAR and their potential role as therpeutic targets. However, due to the prominent role of p, Ak and P2AR in the cardiovascular system, it may be difficult to identify ligands for CNS therapies which lack significant side effects. 

If this country lacks significant energy deposits of any other form, wood assumes an economically viable and totally regenerable fuel source. 

Cucumber, melon, tobacco, and bean varieties, supposedly lacking significant resistance to particular diseases, can be made highly resistant systemically by limited infection prior to severe exposure to pathogens. Injury and non-specific stress do not elicit persistent systemic resistance. 

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