Drug-ligand conjugates

Design of a ligand-drug conjugate linker chemistry... 

Figure 9.2. Structural design of a ligand-targeted drug conjugate.

Figure 4.1. Conventional PM (a) drug-conjugated PM (b) and PICM with the polyionic block consisting of cationic polymer (c) or polynu-cleic acid (antisense oligonucleotides (AON) or small interfering RNA (siRNA)) (d and e). In d and e, the core forming agent is either linear or branched cationic polymer, respectively. Polymer-metal complex micelles formed via the ligand substitution reaction where M and Y are the metal and the ligand, respectively (f).

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