Hepatic microsomal drug metabolizing acid conjugates

Metabolism of antipsychotics is through two mechanisms conjugation with glucuronic acid and oxidation by hepatic microsomal enzymes. Both mechanisms of metabolism and subsequent inactivation take place in the liver. Some degree of enzyme induction may occur because of prolonged use of antipsychotics, which may be responsible for increasing the rate of metabolism of these drugs. 

Fate These drugs are metabolized by the hepatic microsomal system (see p. 14) and conjugated with glucuronic acid. Ultimately, the TCAs are excreted as inactive metabolites via the kidney. 

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