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Drug carriers doxorubicin-conjugated

Micellar systems based on amphipathic block-copolymers have gained most attention as intravenously administered drug carrier systems over the years. These block-copolymers are composed of a hydrophilic PEG block and a hydrophobic block based on doxorubicin conjugated poly(aspartic acid) or poly(/i-bcnzyl L-aspartate). [Pg.123]

Poly(ethylene glycol) (PEG) is a nondegradable synthetic polymer that has been extensively studied as a polymer-drug carrier. PEG is hydrophilic and is well tolerated in human. The main disadvantage of PEG is that the polymer backbone is not biodegradable in vivo. PEG has been used to conjugate anticancer drugs such as doxorubicin [311], camptothecin... [Pg.202]

V. Chytry and K. Ulbrich, Conjugate of doxorubicin with thermosensitive polymer drug carrier, /. Bioactive Compat. Polym., 16, 427-439 (2001). [Pg.58]

Figure 1.3. Structure of PKl (HPMA copolymer doxorubicin), a 28-kDa polymeric carrier-drug conjugate investigated for its anti-tumour activity in a phase I clinical study. Adapted from reference [15]. Figure 1.3. Structure of PKl (HPMA copolymer doxorubicin), a 28-kDa polymeric carrier-drug conjugate investigated for its anti-tumour activity in a phase I clinical study. Adapted from reference [15].
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See also in sourсe #XX -- [ Pg.159 ]



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