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Cancer antibody drug conjugates

Reisfeld, R.A., Yang, H.M., Mullet B., Wargalla, U.C., Schrappe, M., and Wrasidlo, W. (1989) Promises, problems, and prospects of monoclonal antibody-drug conjugates for cancer therapy. Antibody, Immunoconjugates, Radiopharm. 2, 217-224. [Pg.1106]

Trail, P. Bianchi, A. (1999). Monoclonal antibody drug conjugates in the treatment of cancer. Curr. Opin. Immunol. 11(5), 584-588. [Pg.460]

Kovtun YV, Goldmacher VS. Cell killing by antibody-drug conjugates. Cancer Lett. 2007 255(2) 232-240. [Pg.343]

Hamblett Kf, Senter PD, Chace DF, Sun MM, Lenox J, Cerveny CG, Kssler KM, Bernhardt SX, Kopcha AK, Zabinski RF, Meyer DL, Francisco lA (2004) Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate. CUn Cancer Res 10 7063-7070... [Pg.266]

J. Flygare, T. Pillow, P. Aristoff, Antibody-drug conjugates for the treatment of cancer, Chem. Biol. Drug Des. 81 (2013) 113-121. [Pg.231]

Alley SC, Okeley NM, Senter PD. Antibody-drug conjugates targeted drug dehvery for cancer. Current Opinion in Chemical Biology. 2010 14(4) 529-37. [Pg.36]

Bemardes GJL, Casi G, Trussel S, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed. 2012 51 941. ... [Pg.386]

Senter PD. Potent antibody drug conjugates for cancer therapy. Curr Opin Chem Biol. 2009 13 235-44. [Pg.386]

One difficulty with the cytotoxic agents that are used for the treatment of cancer is the differentiation of cytotoxicity between target tumor cells and normal cells. In an innovative approach, the Wyeth group took advantage of a tumor cell-specific drug delivery mechanism of antibodies. They conjugated calicheam-icin (93), perhaps the best described member of the ene-diyne... [Pg.1470]

Pinchera et al. 1985). Antibody-enzyme conjugates are now being used for targeting cytotoxic pro-drugs to cancerous tissue (Chaudhary etal. 1989). In principle, antibody-enzyme conjugates could offer another possible way... [Pg.245]

Griffiths GL, Mattes MJ, Stein R, et al. Cure of SCID mice bearing human B-lymphoma xenografts by an anti-CD74 antibody-anthracycline drug conjugate. Clin Cancer Res 2003 9 6567-65671. [Pg.393]

ADEPT an antibody-beta-lactamase conjugate attacks a cephalopsorin-anti-cancer drug conjugate to liberate the anti-cancer drug... [Pg.218]

Stastny, M., Strohalm, J., Plocova, D., Ulbrich, K. and Rihova, B. (1999) A possibility to overcome P-glycoprotein (PGP)-mediated multidrug resistance by antibody-targeted drugs conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer carrier. Eur. J. Cancer 35 459-466. [Pg.600]

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See also in sourсe #XX -- [ Pg.339 ]



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