Drosophila Toll receptor

Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. A family of human receptors structurally related to drosophila toll. Proc Natl Acad Sci USA 1998 95(2) 588-593. 

Taguchi T, Mitcham JL, Dower SK, Sims JE, Testa JR. 1996. Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4pl4. Genomics 32 486-88... 

Rock, F. L., G. Hardiman, et al. (1998). "A family of human receptors structurally related to Drosophila Toll." Proc Natl Acad Sci USA 95 588-93. 

TLR4 was the first human toll-like receptor found to have homology with Drosophila melanogaster toll [42]. The crystal structure of TLR4 complexed with MD2 and its natural ligand E. coli LPS confirmed that the lipid A portion is the key component for receptor complex binding, consistent with previous biological studies [43]. 

Anderson, K.V., Bokla, L., Nusslein-Volhard, C. Establishment of dorsal-ventral polarity in the Drosophila embryo-, the induction of polarity by the Toll gene product. Cell 42 (1985) 791-798. Baetz, A., Frey, M., Heeg, K., Dalpke, A.H. Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J Biol Chem 279 (2004) 54708-54715. 

Tauszig S, Jouanguy E, Hoffmann JA, Im-ler JL. 2000. From the cover toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc. Natl. Acad. Sci. USA 97 10520-25... 

The proteoglycans in this family, which includes decorin, biglycan, lumican, and fibromodulin, are major components of the interstitial matrix produced by fibroblasts and other cells. The core proteins are small (37-45 kDa) and have several leucine-rich motifs [112] with similarity to the LH-CG receptor, thyrotropin receptor, and Drosophila proteins chaoptin and toll. Core proteins of this family characteristically undergo proteolytic processing following synthesis, with removal of an additional small peptide from the N-terminus. 

Receptors Various in mammals Toll and Toll-like receptors in Drosophila... 

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