Drosophila odorant receptors

Elmore T. and Smith D. P. (2001) Putative Drosophila odor receptor OR43b localizes to dendrites of olfactory neurons. Insect Biochem. Mol. Biol. 31, 791-798. 

Smith D. P. (1999) Drosophila odor receptors revealed. Neuron 22, 203-204. 

Wetzel C. H., Behrendt H., Gisselmann G., Storkuhl K. F., Hovemann B. and Hatt H. (2001) Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system. PNAS 98, 9377-9380. 

This chapter will discuss the isolation of Drosophila odorant receptor (DOR) genes, how these genes have expanded our understanding of the development and functional anatomy of the olfactory system, how the odor response profiles of OSNs respond to odorants, and the mechanisms by which odor-specific activity is relayed to the brain. 

TM, seven transmembrane domain DOR, Drosophila odorant receptor EAG, electroantennogram GFP, green fluorescent protein GPCR, G-protein coupled receptor GR, gustatory receptor nsyb, neuronal synaptobrevin OR, odorant receptor OSN, olfactory sensory neuron PCR, polymerase chain reaction PN, projection neuron RT-PCR, reverse transcription-polymerase chain reaction SOG, subesophageal ganglion. 

Drosophila Odorant Receptor Nomenclature Committee (2000) A unified nomenclature system for the Drosophila odorant receptors. Cell 102, 145-146. 

Baumann A et al (1994) Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae. EMBO J 13 5040-5050 Belluscio L et al (1998) Mice deficient in G(olf) are anosmic. Neuron 20 69-81 Benton R et al (2006) Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. PLoS Biol 4 e20... 

Vosshall LB et al (2000) An olfactory sensory map in the fly brain. Cell 102 147-159 Wanner KW et al (2007) A honeybee odorant receptor for the queen substance 9-oxo-2-decenoic acid. Proc Natl Acad Sci USA 104 14383-14388 Wetzel CH et al (2001) Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system. Proc Natl Acad Sci USA 98 9377-9380 Wicher D et al (2008) Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels. Nature 452 1007-1011 Wilson RI et al (2004) Transformation of olfactory representations in the Drosophila antennal lobe. Science 303 366-370... 

Bader R, Colomb J, Pankratz B, Schrock A, Stocker RF, Pankratz MJ (2007) Genetic dissection of neural circuit anatomy underlying feeding behavior in Drosophila distinct classes of hugin expressing neurons. J Comp Neurol 502 848-856 Benton R, Sachse S, Michnick SW, Vosshall LB (2006) Atypical membrane topology and hetero-meric function of Drosophila odorant receptors in vivo. PLloS Biol 4 e20. 

Wicher D, Schafer R, Bauemfeind R, Stensmyr MC, Heller R, Heinemann SH, Hansson BS (2008) Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels. Nature 452 1007-1011... 

R. Benton et al.. Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. PLOS Biol., 4, e20, 2006. 

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