Cyclic nucleotide-gated channels

Adenylyl Cyclases Guanylyl Cyclases Transmembrane Signalling Cyclic Adenosine Monophosphate Cyclic Guanosine Monophosphate Cyclic Nucleotide-gated Channels Phosphodiesterases... 

Hypeipolarisation-activated and cyclic nucleotide-gated-channel. 

Hyperpolarization-activated and Cyclic Nucleotide-gated Channels (HCN)... 

There are important exceptions to the rule that the physiological effects of cAMP in mammals are achieved via the activation of protein kinase A. The most prominent is a class of ion channels, referred to as HCN (hyperpolarization cyclic nucleotide gated) channels, that directly bind, and are thereby gated by, cAMP. Several forms of HCN channel are widely expressed in brain and peripheral tissues and have been implicated in the regulation of many facets of cell function. 

The cyclic-nucleotide-gated channel is permeable to cations, especially Ca2+. Thus, increased channel activation results in influx of Ca2+ and a transient rise in the intracellular Ca2+ concentration. Intracellular Ca2+ concentrations of 1-3 J,M have been found to lead to a decrease in the open probability of the ion channel, even... 

CNG cyclic nucleotide-gated channel (i) 2, 3 cyclic nucleotide 3 -phosphodiesterase ES embryonic stem cell... 

Genistein (64), an isoflavone found in plants of the family Legu-minosae, is an inhibitor of several protein tyrosine kinases (PTK) and is currently in phase II clinical trials for its potential as an angiogenesis inhibitor. Genistein also has been utilized as a probe to identify binding sites for PTKs by observing the effect it demonstrates on cyclic-nucleotide-gated channels. ... 

MolokanovaE, Kramer RH, Mechanism of inhibition of cyclic nucleotide-gated channel by protein tyrosine kinase probed with genistein, J Gen Physiol 117 219-234, 2001. 

Yau, K.W. Cyclic nucleotide-gated channels an expanding new family of ion channels (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 3481-3483... 

Biel M, Zong X, Ludwig A, Sautter A, Hofmann F (1999) Structure and function of cyclic nucleotide-gated channels. Rev Physiol Biochem Pharmacol 135 151-71 Blackshaw S, Eliasson MJ, Sawa A, Watkins CC, Krug D, Gupta A, Arai T, et al. (2003) Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity. Neuroscience 119 979-90... 

Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, et al. (1996) Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha 1-syntrophin mediated by PDZ domains. Cell 84 757-67 Broillet MC, Firestein S (1996) Direct activation of the olfactory cyclic nucleotide-gated channel through modification of sulfhydryl groups by NO compounds. Neuron 16 377-85... 

Broillet MC, Firestein S (1997) Beta subunits of the olfactory cyclic nucleotide-gated channel form a nitric oxide activated Ca2+ channel. Neuron 18 951-8 Bugnon O, Schaad NC, Schorderet M (1994) Nitric oxide modulates endogenous dopamine release in bovine retina. Neuroreport 5 401—4... 

Kingston PA, Zufall F, Barnstable CJ (1996) Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels novel targets for cAMP/cGMP function. Proc Natl Acad Sd USA 93 10440-5... 

Parent A, Schrader K, Munger SD, Reed RR, Linden DJ, Ronnett GV (1998) Synaptic transmission and hippocampal long-term potentiation in olfactory cyclic nucleotide-gated channel type 1 null mouse. J Neurophysiol 79 3295-301... 

Baumann A., Frings S., Godde M., Seifert R. and Kaupp U.B. (1994) Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae. EMBO J. 13, 5040-5050. 

Bonigk W., Bradley J., Muller F., Sesti F., Boekhoff I., Ronnett G. V., Kaupp U. B. and Frings S. (1999) The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits. J. Neurosci. 19, 5332-5347. 

Broillet M.-C. (2000) A single intracellular cysteine residue is responsible for the activation of the olfactory cyclic nucleotide-gated channel by NO. J. Biol. Chem. 275, 15135— 15141. 

The information reported here is a transcript of a lecture givoi by S. Firestcin on cyclic nucleotide gated channels in olfactory transduction. See abstracts of a symposium at the occasion of the the 40th anniversary of the Unilever research labcaatory in Vlaardingm, Tbe Netherlands, 1996.)... 

Sour taste detects acids, i.e., protons. Several different sour taste receptor candidates such as acid-sensing ion channels (ASICs) (57), hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) (58), and two pore domain potassium channels (K2PS) (59, 60) have been described in the past. In addition, recent research identified two members of the polycystic kidney disease (PKD) family of the transient receptor potential superfamily (TRP) as strong sour taste receptor candidates or as part thereof. Immunohistochemistry and in situ hybridization revealed the presence of the polycystic-kidney-disease-like ion channel PKD2L1 in subsets of taste receptor cells of mouse fungiform, vallate, and foliate papillae. These cells differ from... 

Zheng C, Feinstein P, Bozza T, Rodriguez I, Mombaerts P (2000) Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit. Neuron 26(1) 81-91... 

Michel WC (1999) Cyclic nucleotide-gated channel activation is not required for activity-dependent labeling of zebrafish olfactory receptor neurons by amino adds. Biol Signals Recept 8 338-347 Michel WC, Derbidge DS (1997) Evidence of distinct amino acid and bile salt receptors in the olfactory system of the zebrafish, Danio rerio. Brain Res 764 179-187 Michel WC, Sanderson MJ, Olson JK, Lipschitz DL (2003) Evidence of a novel transduction pathway mediating detection of polyamines by the zebrafish olfactory system. J Exp Biiol 206 1697-1706... 

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