Drosophila melanogaster activity

Kirkpatrick RB, Matico RE, McNulty DE, Strickler JE, Rosenberg M 1995 An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages. Gene 153 147-154 Leconte I, Carpentier JL, Clauser E 1994 The functions of the human insulin receptor are affected in different ways by mutation of each of the four N-glycosylation sites in the fl subunit. J Biol Chem 269 18062-18071... 

N-Nitroso-N-cyclohexylhydroxylamine is a synergistic agent for insecticides [94] it increases the insecticidal activity ofchlordane. Certain N-alkylphenylnitrosamines [95] and alkyl N-alkyl-N-nitrosocarbamates [96] are insecticides and fungicides, and may also be used for the impregnation of fabrics, etc. They have larvicidal action against Drosophila melanogaster and can also kill all moth larvae and weevils. 

Octopamine in the CNS. It is reasonable to suppose that this handful of varied systems where OA has effector functions is only the tip of the iceberg and that more will be discovered. All of these known systems are located peripherally since the demonstration of a specific transmitter role for any compound within the CNS is very challenging. However, there is every reason to believe that OA has important transmitter or modulator functions in the CNS of arthropods. It is synthesized and stored there in plausible amounts (8,9f13) and OA-sensitive adenylate cyclase activity has been found within the CNS of several arthropods. In addition to the examples cited in the recent review by Bodnaryk (26), this activity has been demonstrated in the tobacco hornworm (27f28), Drosophila melanogaster (29)t the tick, Amblyomma hebraeum (27) and the crayfish (30,31) Neurones specifically sensitive to OA have been... 

Tsukamoto T, Ishikawa Y, Miyazawa M, Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster, J Agric Pood Chem 53 5549-5553, 2005. 

Vogel, E., Blijleven, W.G.H., Kortselius, M.J.H. and Zijlstra, J.A. (1981) Mutagenic activity of 17 coded compounds in the sex-linked recessive lethal test in Drosophila melanogaster, in Progress in Mutation Research, Volume 1 Evaluation of Short-Term Tests Carcinogens (eds F.J. de Serres and J. Ashby), Elsevier, Amsterdam. 

A small increase in somatic mutation frequency was reported in the eye-colour spot test with Drosophila melanogaster exposed to di(2-ethylhexyl) phthalate in the feed but no effect was observed in two independent wing-spot tests. In a single study, mitotic recombination was not induced by di(2-ethylhexyl) phthalate neither was sex-linked recessive lethal mutation induced in two studies in D. melanogaster treated with di(2-ethylhexyl) phthalate in the feed or by injection. When administered to D. melanogaster, di(2-ethylhexyl) phthalate and A-nitrosodiethylamine induced DNA double-strand breakage and DNA repair, although neither compound was active when administered alone. 

Kawai, K. (1998) Enhancement of the DNA damaging activity of A -nitrosodimethylamine by di-(2-ethylhexyl)phthalate in somatic cells in vivo of Drosophila melanogaster. Biol, pharm. Bull, 21, 579-582... 

Coumarin did not induce micronuclei in mice in vivo and was not mutagenic in Drosophila melanogaster. It was weakly positive in induction of micronuclei in htunan cells in vitro, but failed to induce tmscheduled DNA synthesis in human liver cells in vitro. Coumarin induced sister chromatid exchanges without metabolic activation and chromosomal aberrations with metabolic activation, but not micronuclei or gene mutations in mammalian cells in vitro. It was mutagenic in only two out of 11 Salmonella typhimurium strains tested, with metabolic activation. 

Fahmy, M.J. Fahmy, O.G (1984) Genetic activity of the carcinogen A-nitrosodiethanol-amine (NDELA) on unstable mutant alleles of the white locus in Drosophila melanogaster. Teratog. Carcinog. Mutag., 4, 437-447... 

Munch-Petersen, B. Piskur, J. Sondergaard, L. Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single mono-... 

A correlation was also presented between life-span and (Cu,Zn)- plus (Mn)-SOD activities of two strains of Drosophila melanogaster. The short-living vestigial strain had an activity of 72% on the average of the wild strain With 2 rodent and 12 primate species there was a good correlation between the ratio of SOD activity to specific metabolic rate and the maximum life-span potential for the brain, heart, and liver... 

Acetaldehyde causes gene mutations in bacteria and gene mutations, sister chromatid exchanges, micronuclei and aneuploidy in cultured mammalian cells, without metabolic activation. In vivo, it causes mutations in Drosophila melanogaster but not micronuclei in mouse germ cells. It causes DNA damage in cultured mammalian cells and in mice in vivo. Acetaldehyde-DNA adducts have been found in white blood cells from human alcohol abusers. 

Fahmy, M.J. Fahmy, O.G. (1982) Genetic activities of 4-chloromethylbiphenyl, the 4-hydroxy derivative and benzyl chloride in the soma and germ line of Drosophila melanogaster. Mutat. Res., 100, 339-344... 

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